...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Laboratory Animal Science >Behavioral effects of ivermectin in mice.
【24h】

Behavioral effects of ivermectin in mice.

机译：伊维菌素在小鼠中的行为作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The action of ivermectin on sensitive behavioral tasks in mice, during treatment for mites within a barrier facility, was investigated. 21 (5 males, 16 females) mice (129/SvEv) were used for measuring body weight, open field locomotor activity and rotarod motor coordination. For acoustic startle and prepulse inhibition, 20 C57BL/6J and 29 AKR/J mice were studied. For the Morris water task, the same 20 C57BL/6J mice were studied. Ivermectin (0.08% sheep drench) was administered in the drinking waterof the home cage for 8 weeks. Control groups received normal tap water. Ivermectin did not affect general health, body weight, motor coordination, swimming behaviour, or spatial learning in several inbred strains of mice, but it induced a small but significant effect on some sensitive behaviours, including exploration of a novel open field, the acoustic startle reflex and prepulse inhibition of the acoustic startle reflex, a measure of sensorimotor gating. It is concluded that a cautious approach to initiating ivermectin treatment in mice should be used for sensitive behavioural experiments.
机译：研究了伊维菌素对隔离设施内螨虫治疗过程中小鼠敏感行为任务的作用。使用21只（5只雄性，16只雌性）小鼠（129 / SvEv）来测量体重，开阔地运动能力和轮足运动协调性。为了抑制声音惊吓和预脉冲，研究了20只C57BL / 6J和29只AKR / J小鼠。对于莫里斯水任务，研究了相同的20只C57BL / 6J小鼠。在家庭笼的饮用水中施用伊维菌素（0.08％的羊水）8周。对照组接受普通自来水。伊维菌素对几种近交系小鼠的整体健康，体重，运动协调，游泳行为或空间学习均没有影响，但它对某些敏感行为产生了小而显着的影响，包括探索新的开放视野，声音惊吓反射和前脉冲抑制听觉惊吓反射，这是感觉运动门控的一种度量。结论是在敏感的行为实验中应谨慎使用伊维菌素治疗小鼠。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号