EFFICACY OF A TEMPERATURE-SENSITIVE SENDAI VIRUS VACCINE IN HAMSTERS

Tagaya M; Mori I; Miyadai T; Kimura Y; Ito H; Nakakuki K

首页> 外文期刊>Laboratory Animal Science >EFFICACY OF A TEMPERATURE-SENSITIVE SENDAI VIRUS VACCINE IN HAMSTERS

【24h】

EFFICACY OF A TEMPERATURE-SENSITIVE SENDAI VIRUS VACCINE IN HAMSTERS

机译：仓鼠中温度敏感的仙台病毒疫苗的功效

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A temperature-sensitive HVJ-pB strain of parainfluenza type 1 (Sendai) virus was obtained from a persistently virus-infected cell culture. Intranasal inoculation of Syrian hamsters with the HVJ-pB temperature-sensitive mutant resulted in an abortive infection but induced a specific antibody response against Sendai virus without appreciable lesions in the respiratory tract. Prior exposure to the temperature-sensitive mutant protected hamsters from subsequent challenge with virulent wild-type virus. The efficacy of protection became apparent at 5 days after vaccination and lasted for at least 720 days. For practical use of the HVJ-pB vaccine, a single intranasal administration to newborn babies aged over 15 days is recommended.

机译：从持续感染病毒的细胞培养物中获得了1型副流感病毒（仙台）的温度敏感HVJ-pB株。用HVJ-pB温度敏感突变体对叙利亚仓鼠进行鼻内接种可导致流产感染，但可诱导针对仙台病毒的特异性抗体反应，而呼吸道无明显损伤。事先暴露于温度敏感突变体可保护仓鼠免受随后用强毒野生型病毒攻击。疫苗接种后5天，保护作用变得明显，并持续至少720天。为了实际使用HVJ-pB疫苗，建议对15天以上的新生儿进行一次鼻内给药。

著录项

来源
《Laboratory Animal Science》 |1995年第3期|共6页
作者
Tagaya M; Mori I; Miyadai T; Kimura Y; Ito H; Nakakuki K;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类动物学实验（实验动物学）、动物学技术;
关键词
Infection; Mutant; Cells; Mice; Glycoproteins; Protection;

机译：感染;突变;细胞;小鼠;糖蛋白;保护;

相似文献

外文文献
中文文献
专利

1. EFFICACY OF A TEMPERATURE-SENSITIVE SENDAI VIRUS VACCINE IN HAMSTERS [J] . Tagaya M, Mori I, Miyadai T, Laboratory Animal Science . 1995,第3期

机译：仓鼠中温度敏感的仙台病毒疫苗的功效
2. Efficacy of an intranasal modified live bovine respiratory syncytial virus and temperature-sensitive parainfluenza type 3 virus vaccine in 3-week-old calves experimentally challenged with PI3V [J] . Vangeel I, Ioannou F, Riegler L, The Veterinary Journal . 2009,第1期

机译：鼻内修饰的活牛呼吸道合胞病毒和对温度敏感的3型副流感病毒疫苗在用PI3V实验性攻击的3周龄小牛中的功效
3. Long-Term Single-Dose Efficacy of a Vesicular Stomatitis Virus-Based Andes Virus Vaccine in Syrian Hamsters [J] . Blair L. DeBuysscher, Heinz Feldmann, Joseph Prescott, Viruses . 2014,第2期

机译：叙利亚仓鼠中基于水泡性口腔炎病毒的安第斯病毒疫苗的长期单剂量疗效
4. Vaccine efficacy of live-attenuated virus, whole-virus inactivated and alphavirus vectored subunit vaccines against antigenically distinct H3N2 swine influenza A viruses [C] . Eugenio J. Abente, Nicola S. Lewis, Mark A. Mogler, Annual^Meeting of the American^Association^of^Swine^Veterinarians. . 2016

机译：活病毒的疫苗疗效，全病毒灭活和alphavirus向量亚单位疫苗反对抗原性不同的H3N2猪流感病毒
5. Temperature-sensitive Phenotype of a Mutant Sendai Virus Strain Is Caused by Its Insufficient Accumulation of the M protein [D] . 近藤, 亨 1994

机译：突变的仙台病毒株的温度敏感表型是由其M蛋白积累不足引起的
6. Efficacy of Killed Virus Vaccine Live Attenuated Chimeric Virus Vaccine and Passive Immunization for Prevention of West Nile virus Encephalitis in Hamster Model [O] . Robert B. Tesh, Juan Arroyo, Amelia P.A. Travassos da Rosa, 2002

机译：杀死病毒疫苗减毒的嵌合病毒活疫苗和被动免疫预防仓鼠模型中的西尼罗河病毒性脑炎的功效
7. Efficacy of Killed Virus Vaccine, Live Attenuated Chimeric Virus Vaccine, and Passive Immunization for Prevention of West Nile virus Encephalitis in Hamster Model [O] . Tesh, Robert B., Arroyo, Juan, Travassos da Rosa, Amelia P.A., 2002

机译：杀死病毒疫苗，减毒的嵌合病毒活疫苗和被动免疫在仓鼠模型中预防西尼罗河病毒性脑炎的功效
8. Protective Efficacies of Live Attenuated and Formaldehyde-Inactivated Venezuelan Equine Encephalitis Virus Vaccines Against Aerosol Challenge in Hamsters [R] . Jahrling, P. B., Stephenson, E. H. 1984

机译：活减毒和甲醛灭活的委内瑞拉马脑炎病毒疫苗对仓鼠气溶胶攻击的保护作用

EFFICACY OF A TEMPERATURE-SENSITIVE SENDAI VIRUS VACCINE IN HAMSTERS

摘要

著录项

相似文献

相关主题

期刊订阅