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首页> 外文期刊>Laboratory Animal Science >DIABETES MELLITUS AND ISLET AMYLOIDOSIS IN CYNOMOLGUS MONKEYS
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DIABETES MELLITUS AND ISLET AMYLOIDOSIS IN CYNOMOLGUS MONKEYS

机译：食蟹猴的糖尿病和胰岛淀粉样变性

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摘要

Six 15- to 20-year old obese cynomolgus monkeys were determined to have diabetes mellitus. These monkeys were hyperglycemic and hypertriglyceridemic, yet remained nonketotic for several years before requiring clinical intervention, A significant decrease in glucose disappearance and an increased area under the glucose disappearance curve were found in response to intravenous glucose tolerance testing. Basal hyperinsulinemia was found in three animals that, in response to glucose stimulation, had a blunted insulin response, resulting in an overall decrease in the area under the insulin curve, Two animals died during the study and had extensive amyloid infiltration of pancreatic islets. The combined findings of old age, obesity, hyperinsulinemia, improvement in response to caloric restriction, and islet amyloidosis are consistent with type 2 diabetes mellitus.
机译：确定六只15至20岁的肥胖食蟹猕猴患有糖尿病。这些猴子具有高血糖和高甘油三酸酯血症，但在需要临床干预之前仍保持非酮症状态。响应静脉内葡萄糖耐量试验，发现了葡萄糖消失的显着减少和葡萄糖消失曲线下面积的增加。在三只动物中发现了基础性高胰岛素血症，这些动物在响应葡萄糖刺激后胰岛素反应减弱，导致胰岛素曲线下的面积总体减少。在研究中有两只动物死亡，并且胰岛淀粉样蛋白广泛浸润。老年，肥胖，高胰岛素血症，对热量限制的反应改善和胰岛淀粉样变性的综合发现与2型糖尿病一致。

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