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首页> 外文期刊>Laboratory Animal Science >THE EFFECT OF COMBINED ROTAVIRUS AND ESCHERICHIA COLI INFECTIONS IN RABBITS
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THE EFFECT OF COMBINED ROTAVIRUS AND ESCHERICHIA COLI INFECTIONS IN RABBITS

机译：轮状病毒和大肠埃希氏菌联合感染对家兔的影响

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In rabbits, experimentally induced rotavirus infection results in soft feces only; thus it is unlikely that it is the sole cause of the severe, often fatal diarrhea of weanling rabbits with which it is associated. To determine whether rotavirus acts synergistically with another pathogen, New Zealand White rabbits (10 to 38 weeks old) were inoculated with rotavirus (L:ALA:84) and/or Escherichia coli 015:H-(RDEC-1) via orogastric tube. A single dose of high-titer (10(6) fluorescent focus-forming units) rotavirus was used, whereas E. coli was administered in various doses (10(2) to 10(9) CFU) to determine the titer off. coli that induced only mild diarrhea but, when combined with rotavirus, resulted in diarrheal disease. Doses off. coli >10(6) CFU resulted in infection in almost all rabbits 10 to 16 weeks old, as detected by fecal shedding, regardless of whether rotavirus was inoc ulated simultaneously. However, inoculation of >10(6) CFU of E. coli, in conjunction with rotavirus, resulted in increased morbidity and mortality due to diarrheal disease compared with E. coli alone. Inoculation of rabbits 28 to 38 weeks old with similar doses of rotavirus and E. coli caused infection but failed to induce diarrhea, indicating that older rabbits were more resistant to the pathogenic effects of these two agents. A synergistic effect between rotavirus and E. coli occurred, causing more severe diarrheal disease in weanling rabbits than that resulting from either pathogen alone.
机译：在兔子中，实验诱导的轮状病毒感染只会导致粪便柔软;因此，它不可能是与之相关的断奶兔子严重，经常致命的腹泻的唯一原因。为了确定轮状病毒是否与另一种病原体协同作用，通过轮胎胃管向轮状病毒（L：ALA：84）和/或大肠杆菌015：H-（RDEC-1）接种新西兰白兔（10至38周龄）。使用单剂量的高滴度（10（6）个荧光焦点形成单位）轮状病毒，而以不同剂量（10（2）至10（9）CFU）施用大肠杆菌以确定滴度。仅引起轻度腹泻的大肠杆菌，当与轮状病毒结合使用时，会导致腹泻病。放下。通过粪便脱落检测到，无论是否同时接种轮状病毒，大肠杆菌> 10（6）CFU都会在几乎所有10至16周大的兔子中引起感染。然而，与单独的大肠杆菌相比，与轮状病毒结合接种大于10（6）CFU的大肠杆菌会导致发病率和死亡率的增加。用相似剂量的轮状病毒和大肠杆菌接种28至38周龄的兔子可引起感染，但未能引起腹泻，这表明年龄较大的兔子对这两种药物的致病作用更具抵抗力。轮状病毒和大肠杆菌之间发生了协同作用，导致断奶兔子的腹泻病比单独的两种病原体引起的腹泻病更为严重。

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