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首页> 外文期刊>Laboratory Animal Science >ACUTE NEUROLOGIC DECOMPRESSION ILLNESS IN PIGS - LESIONS OF THE SPINAL CORD AND BRAIN
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ACUTE NEUROLOGIC DECOMPRESSION ILLNESS IN PIGS - LESIONS OF THE SPINAL CORD AND BRAIN

机译：猪的急性神经系统减压病-脊髓和脑部病变

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摘要

A detailed histopathologic description of central nervous system lesions from a porcine model of neurologic decompression illness is presented. Pigs were dived in a dry chamber to 200 feet of seawater for 24 min before the start of decompression. Of 120 pigs, 40 (33.3%) were functionally unaffected and 80 (66.6%) developed neurologic decompression illness; 16 died, 64 survived. Petechial hemorrhages were grossly visible in the spinal cord of 73% of the survivors, 63% of the fatalities, and 3% of the clinically unaffected pigs. The thoracic part of the cord was most commonly involved. Histologic cord lesions were found in 75 (63%) pigs: 83% of decompression illness survivors, 81% of the fatalities, and 23% of those clinically unaffected. Morphologically, hemorrhagic lesions were the most common (54%). Other common findings included spongiosis (48%), axonal swelling and loss (39%), and myelin degeneration (35%). White matter hemorrhages in the spinal cord were generally more numerous and extensive than those affecting the gray matter; however, gray matter hemorrhage was associated with increasing disease severity. Brain lesions were present in 23% of pigs and were most frequent in fatalities. Cerebellar and brain stem hemorrhages were the most common brain lesions; the molecular layer of the cerebellum appeared particularly susceptible. Pigs were chosen because of their cardiovascular and gas exchange similarities to humans. The clinical and histopathologic features of the pig model were compared with previous accounts in animals and humans; the model was judged analogous to severe human decompression illness. The finding of occult brain and cord lesions in clinically unaffected pigs is discussed. The model provides a useful tool for the study of dysbaric lesions of the central nervous system. Its noninvasive nature may facilitate the study of nervous system injury and repair processes.
机译：提出了从神经性减压病的猪模型中枢神经系统病变的详细组织病理学描述。开始减压之前，将猪在干燥的室内潜水至200英尺的海水中24分钟。在120头猪中，有40头（33.3％）在功能上未受影响，其中80头（66.6％）发展为神经系统减压病; 16死亡，64幸存。在73％的幸存者，63％的死亡人数和3％的临床未受影响的猪的脊髓中明显可见小儿出血。脐带的胸部分最常见。在75头（63％）的猪中发现了组织学损伤：减压病幸存者中有83％，死亡人数中有81％，临床未受影响者中有23％。从形态上讲，出血性病变最为常见（54％）。其他常见发现包括海绵状变性（48％），轴突肿胀和缺失（39％）和髓鞘变性（35％）。脊髓中的白质出血通常比影响灰质的出血更为广泛和广泛。然而，灰质出血与疾病严重程度增加有关。 23％的猪存在脑部病变，死亡人数最多。小脑和脑干出血是最常见的脑部病变。小脑的分子层显得特别敏感。选择猪是因为它们与人的心血管和气体交换相似。将该猪模型的临床和组织病理学特征与先前在动物和人类中的描述进行了比较;该模型被认为类似于严重的人类减压病。讨论了在临床上未受影响的猪中发现隐匿性脑和脊髓损伤的发现。该模型为研究中枢神经系统的减压障碍提供了有用的工具。它的无创性可以促进神经系统损伤和修复过程的研究。

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