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首页> 外文期刊>Laboratory Animal Science >THE REPEATED SAMPLING BONE CHAMBER - A NEW PERMANENT TITANIUM IMPLANT TO STUDY BONE GRAFTS IN THE GOAT
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THE REPEATED SAMPLING BONE CHAMBER - A NEW PERMANENT TITANIUM IMPLANT TO STUDY BONE GRAFTS IN THE GOAT

机译：重复的采样骨腔-一种新的永久性钛植入物，用于研究山羊的骨移植物

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摘要

We developed a repeated sampling bone chamber (RSBC) and tested its suitability for studying various aspects of the bone allograft incorporation process under reproducible nonload-bearing experimental conditions in a large vertebrate, Our chamber is made of commercially pure titanium and is designed to allow bone or tissue ingrowth into a removable hollow inner core, Three chambers per animal were randomly implanted in the tibias of 10 goats and were harvested every 8 weeks, In experiment 1, two chambers were filled with a fresh-frozen structural allograft or a chip allograft, and one was left empty, In experiment 2, all chambers were left empty to measure intra-and interanimal variation. The results were evaluated by histomorphometry. Clinical results of four growth factor experiments also are presented.
机译：我们开发了一个重复采样的骨腔（RSBC），并测试了其适用于在大型脊椎动物中在可重现的非承重实验条件下研究同种异体骨植入过程的各个方面的适用性。我们的腔室由商业纯钛制成，旨在允许骨骼或将组织向内生长到可移动的空心内核中，每只动物三个腔室随机植入10只山羊的胫骨中，每8周收获一次。在实验1中，两个腔室填充有新鲜冷冻的同种异体移植物或片状同种异体移植物，在实验2中，所有小室都留空以测量动物内和动物间的差异。通过组织形态计量学评估结果。还介绍了四个生长因子实验的临床结果。

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