• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Laboratory Animal Science >Oral anticoagulant therapy and international normalized ratios in Swine
【24h】

Oral anticoagulant therapy and international normalized ratios in Swine

机译：口服抗凝治疗和国际标准化猪比例

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

While monitoring coagulation testing in Yucatan miniature swine being given oral anticoagulants, we noticed instances of high international normalized ratios (INR) without clinical complications in our animal model. All pigs (n = 17) weighed approximately 35.2 kg and were dosed daily with 2 to 3 mg of coumadin. Plasma samples were obtained and assayed for prothrombin time (PT), calculated INR, and activated partial thromboplastin time (APTT) at baseline, and after 7 and 14 days of coumadin therapy. Results of initial testing indicated high INR values after anticoagulation and short APTT values at baseline, which led us to consider the activity of vitamin K-dependent coagulation factors in the pig. This information was not available in literature concerning this strain of swine, and was surprising given that pigs are frequently used cardiac research models. Using the same plasma samples, we repeated the PT, INR, and APTT determinations using different reagents and a different analyzer. We also determined activities of coagulation factors II, VII, IX, and X. Large PT and INR differences were seen between the two instrument/reagent combinations, possibly due to the differences in the thromboplastins used and differences in the photo-optic versus manual clot-detection method of the instruments. Vitamin K-dependent factors in all pigs responded to coumadin by decreasing to <30.0% activity, except for factor IX. The high INR values were not as pronounced when the second instrument/reagent combination was used, and the results seemed more in line with the animals' clinical condition. With this instrument/reagent combination, the pig can be considered a good model for research requiring oral anticoagulant medication.
机译：在监测被给予口服抗凝剂的尤卡坦小型猪的凝血测试时，我们注意到在动物模型中国际标准化比高（INR）且没有临床并发症的情况。所有猪（n = 17）重约35.2公斤，每天服用2至3毫克香豆素。获得血浆样品，并在基线和香豆素治疗7天和14天后测定凝血酶原时间（PT），计算的INR和活化的部分凝血活酶时间（APTT）。初步测试结果表明抗凝后INR值较高，基线时APTT值较短，这使我们考虑了猪中维生素K依赖性凝血因子的活性。该信息在有关该猪株的文献中尚无可用，鉴于猪是经常使用的心脏研究模型，因此令人惊讶。使用相同的血浆样品，我们使用不同的试剂和不同的分析仪重复进行PT，INR和APTT的测定。我们还确定了凝血因子II，VII，IX和X的活性。两种仪器/试剂组合之间的PT和INR差异较大，这可能是由于使用的促凝血酶原蛋白的差异以及光凝与手动凝块的差异-仪器的检测方法。除因子IX外，所有猪中的维生素K依赖性因子对香豆素的反应均降低至<30.0％。当使用第二种仪器/试剂组合时，高INR值并不那么明显，结果似乎更符合动物的临床状况。通过这种仪器/试剂的组合，可以认为猪是需要口服抗凝药物的良好模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号