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首页> 外文期刊>Caries research >Remineralisation of Enamel Lesions with Daily Applications of a High-Concentration Fluoride Gel and a Fluoridated Toothpaste: An in situ Study.
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Remineralisation of Enamel Lesions with Daily Applications of a High-Concentration Fluoride Gel and a Fluoridated Toothpaste: An in situ Study.

机译：日常应用高浓度氟化物凝胶和氟化牙膏对牙釉质病变的再矿化：原位研究。

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摘要

The inhibition of enamel demineralisation and the enhancement of remineralisation are positively but not linearly related to the concentration of fluoride, especially when high fluoride concentrations are used. The aim of this in situ experiment was to determine the maximum amount of enamel remineralisation that can be achieved with daily applications of very high concentrations of fluoride. For this purpose we compared the efficacy of a daily application of fluoridated topical gel (12,500 ppm F, partly as NaF, Olafluor and Dectafluor, pH 4.5) in combination with a fluoridated toothpaste (1,450 ppm F as NaF), with fluoridated toothpaste alone. Participants (n = 26, with partial dentures) were fitted with a demineralised enamel specimen (mean mineral loss of 1,674 vol%.&mgr;m) and were instructed to use one of the two fluoride treatments. After 4 weeks of treatment, the specimens were retrieved, a section was cut and analysed with microradiography. The remainder of each of the specimens was used for analysis of the 'loosely bound' and 'bound' fluoride. Fluoride was measured with gas-liquid chromatography. After 4 weeks in the mouth, the original lesion was reduced in size by 54% in the toothpaste + gel group (n = 14) and by 44% in the toothpaste-only group (n = 12), but the difference between the groups was not statistically significant. The mineral content profiles showed remineralisation of the lesions throughout the depth of the lesion. The enhancement of remineralisation by the high amounts of fluoride was most pronounced in the surface layer. For both the 'loosely bound' and 'bound' fluoride, a statistically significant increase in fluoride concentration could be found in the toothpaste + gel group. In the 4-week in situ period the use of high amounts of fluoride resulted in a maximum remineralisation rate. This is illustrated by an increase in remineralisation and higher fluoride concentrations in the toothpaste + gel group compared to the toothpaste-only group. Copyright 2002 S. Karger AG, Basel
机译：搪瓷脱矿的抑制和再矿化的增强与氟化物的浓度呈正相关，但不是线性相关，尤其是在使用高氟化物浓度时。此原位实验的目的是确定每天使用非常高浓度的氟化物可获得的最大搪瓷再矿化量。为此，我们比较了每天使用氟化局部用凝胶（12,500 ppm F，部分为NaF，Olafluor和Dectafluor，pH 4.5）与氟化牙膏（1,450 ppm F如NaF）联合单独使用氟化牙膏的功效。参与者（n = 26，有局部义齿）配有脱矿质的牙釉质标本（平均矿物质损失为1,674 vol％.m），并被指示使用两种氟化物处理方法之一。处理4周后，取回标本，切下切片并用显微放射线照相术进行分析。每个样品的其余部分用于分析“松散结合”和“结合”氟化物。用气-液相色谱法测量氟化物。入口腔4周后，在牙膏+凝胶剂组（n = 14）中，原始病变的大小减少了54％，在仅牙膏的组中（n = 12）减少了44％，但是各组之间的差异没有统计学意义。矿物质含量分布图显示了在整个病变深度处的病变再矿化。在表层中，大量氟化物对再矿化作用的增强最为明显。对于“松散结合”和“结合”的氟化物，在牙膏+凝胶剂组中发现了统计学上显着的氟化物浓度增加。在原位的4周内，使用大量的氟化物可实现最大的再矿化率。与仅使用牙膏的组相比，牙膏+凝胶组中的矿化增加和氟化物浓度升高可以说明这一点。版权所有2002 S. Karger AG，巴塞尔

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