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Supercritical Fluid Chromatography (SFC): A Review of Technical Developments

机译：超临界流体色谱（SFC）：技术发展回顾

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摘要

Over the past 20 years, supercritical fluid chromatography has had its share of successes and failures. However, with recent technological advances and a widespread application in pharmaceutical analysis and purification, its future now looks very secure. In the mid 1980s the chromatographic application of gases compressed (or liquefied) to supercritical state was tested by research teams from several analytical instrument manufacturers. The recently introduced capillary columns seemed ideal candidates on which to perform such supercritical fluid chromatography (SFC) methods. In addition, gas chromatography (GC) detectors, including flame ionization, electron capture and nitrogen phosphorous, were optimized for SFC with additional heating zones to take into account adiabatic cooling during the decompression phase. In these early days, the targeted application areas were primarily in the petrochemical industry. It is interesting to note that most pioneers from the pharmaceutical industry who tested the available instruments found the technology very limited, if not almost useless. As a consequence of this, in the early 1990s, the technology almost died through lack of application to the pharmaceutical market.
机译：在过去的20年中，超临界流体色谱具有成功和失败的部分。但是，随着最近的技术进步以及在药物分析和纯化中的广泛应用，其未来现在看起来非常安全。在1980年代中期，来自多家分析仪器制造商的研究小组对压缩（或液化）至超临界状态的气体进行了色谱分析。最近引入的毛细管柱似乎是执行此类超临界流体色谱（SFC）方法的理想候选对象。此外，气相色谱（GC）检测器（包括火焰离子化，电子捕获和氮磷）已针对SFC进行了优化，并带有额外的加热区，以考虑减压阶段的绝热冷却。在早期，目标应用领域主要是石油化工行业。有趣的是，大多数测试可用仪器的制药业先驱发现该技术非常有限，即使不是几乎没有用。结果，在1990年代初期，该技术几乎因缺乏在制药市场上的应用而消失。

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