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首页> 外文期刊>Cell biology international. >HYPERTHERMIC STRESS MODULATES THE FUNCTIONS OF RAT LIVER GLUCOCORTICOID RECEPTOR
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HYPERTHERMIC STRESS MODULATES THE FUNCTIONS OF RAT LIVER GLUCOCORTICOID RECEPTOR

机译:高体温应激调节大鼠肝糖皮质激素受体的功能

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摘要

A mild whole body hyperthermic stress causes a rapid and reversible reduction of rat liver glucocorticoid receptor (GR) binding capacity and affects the stability of the GR-DNA complexes formed after thermal transformation of the receptor. These changes appear to be physiologically relevant, since they are accompanied by a decrease in dexamethasone induction of hepatic tyrosine aminotransferase (TAT). In spite of the decreased rate of the GR degradation in Liver cytosol of hyperthermic as compared to control rats, the total amount of the GR and its proteolytic products recognized by BuGR2 monoclonal antibody was found to be lower in the former cytosol, bur higher in the respective nuclei.
机译:轻度的全身高温应激会导致大鼠肝糖皮质激素受体(GR)的结合能力快速且可逆地降低,并影响受体热转化后形成的GR-DNA复合物的稳定性。这些变化似乎与生理相关,因为它们伴随着地塞米松诱导的肝酪氨酸氨基转移酶(TAT)的减少。尽管与对照大鼠相比,高热肝细胞溶胶中GR降解的速率降低,但BuGR2单克隆抗体识别的GR及其蛋白水解产物的总量在前一个细胞溶胶中较低,而在较高的细胞质中bur较高。各自的核。

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