THE DNA BINDING AFFINITY OF RAT LIVER NUCLEOPROTEINS TO THE REGULATORY ELEMENTS OF THE HAPTOGLOBIN AND ALPHA(2)-MACROGLOBULIN GENES

Petrovic M; Bogojevic D; Grigorov I; Sevaljevic L

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THE DNA BINDING AFFINITY OF RAT LIVER NUCLEOPROTEINS TO THE REGULATORY ELEMENTS OF THE HAPTOGLOBIN AND ALPHA(2)-MACROGLOBULIN GENES

机译：大鼠肝核蛋白对肝素和α（2）-巨球蛋白基因调控元件的DNA结合亲和力

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Transcriptional regulation and binding interactions between soluble nucleoproteins and the hormone response elements (REs) of the rat haptoglobin (Hp) and alpha(2)-macroglobulin (alpha(2)MG) genes was examined in the livers of rats during the acute-phase reaction. Our results demonstrate that the elevation of the Hp and alpha(2)MG genes' transcription rates in acute-phase liver relies essentially on an increase in the binding-affinity of pre-xisting soluble nucleoproteins, enhancing their capability to bind the examined cis-regulatory elements. The 35kD nucleoprotein that displayed an acute-phase inducible affinity to bind hormone REs of rat Hp and (alpha(2)MG genes, was identified as a C/EBP beta isoform.

机译：在急性期期间，在大鼠肝脏中检查了可溶性核蛋白与大鼠触觉珠蛋白（Hp）和α（2）-巨球蛋白（alpha（2）MG）基因的激素反应元件（RE）之间的转录调控和结合相互作用反应。我们的研究结果表明，急性期肝脏中Hp和alpha（2）MG基因的转录速率的升高主要取决于预先存在的可溶性核蛋白的结合亲和力的增加，从而增强了它们结合被检测的顺式核糖核酸的能力。监管要素。 35kD核蛋白表现出急性期诱导亲和力结合大鼠Hp和（alpha（2）MG基因的激素REs，被确定为C / EBP beta亚型。

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《Cell biology international.》 |1995年第12期|共6页
作者
Petrovic M; Bogojevic D; Grigorov I; Sevaljevic L;
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正文语种 eng
中图分类细胞生物学;
关键词
Haptoglobin; Alpha(2) macroglobulin genes; Dna binding proteins; Acute phase protein;

机译：触珠蛋白;α（2）巨球蛋白基因;Dna结合蛋白;急性期蛋白;

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1. THE DNA BINDING AFFINITY OF RAT LIVER NUCLEOPROTEINS TO THE REGULATORY ELEMENTS OF THE HAPTOGLOBIN AND ALPHA(2)-MACROGLOBULIN GENES [J] . Petrovic M, Bogojevic D, Grigorov I, Cell biology international. . 1995,第12期

机译：大鼠肝核蛋白对肝素和α（2）-巨球蛋白基因调控元件的DNA结合亲和力
2. Nuclear localization and binding affinity of STAT5b for the alpha(2)-macroglobulin gene promoter during rat liver development and the acute-phase response [J] . Mihailovic M, Dinic S, Bogojevic D, Acta Biochimica Polonica . 2007,第2期

机译：STAT5b在大鼠肝脏发育和急性期反应中对α（2）-巨球蛋白基因启动子的核定位和结合亲和力
3. p53-LIKE PROTEIN BINDING AFFINITY TO THE HORMONE RESPONSIVE ELEMENT OF THE HAPTOGLOBIN GENE IN FETAL RAT LIVER. [J] . Bogojevic D, Petrovic M, Mihailovic M Cell biology international. . 2002,第3期

机译：类似于p53的蛋白与胎儿大鼠肝中肝素基因的激素反应元件具有良好的结合力。
4. Molecular Dynamic Simulations Suggest that P152R Mutation Within MeCP2 Can Lead to Higher DNA Binding Affinity and Loss of Selective Binding to Methylated DNA [C] . Dino Franklin International Conference on Practical Applications of Computational Biology and Bioinformatics . 2019

机译：分子动态模拟表明，MECP2内的P152R突变可以导致更高的DNA结合亲和力和对甲基化DNA的选择性结合的丧失
5. Comparative studies on the binding of pregnancy zone protein (PZP) and alpha-2-macroglobulin (alpha(2)M) to cytokines including placental protein 14 (PP14) and their immunomodulatory effect on PP14 [D] . Skornicka, Erin Lynette. 2001

机译：对妊娠区蛋白（PZP）和α-2-甲基纤维素（α（2）M）与胎盘蛋白14（PP14）的细胞因子的比较研究及其对PP14的免疫调节作用及其免疫调节作用
6. A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin alpha 1-antitrypsin albumin and simian virus 40 genes. [O] . R H Costa, D R Grayson, K G Xanthopoulos, 1988

机译：肝脏特异性DNA结合蛋白可识别运甲状腺素蛋白α1-抗胰蛋白酶白蛋白和猿猴病毒40基因的调控区域中的多个核苷酸位点。
7. Nuclear localization and binding affinity of STAT5b for the alpha(2)-macroglobulin gene promoter during rat liver development and the acute-phase response. [O] . Mirjana Mihailović, Svetlana Dinić, Desanka Bogojević, 2007

机译：核定位和Stat5b对大鼠肝脏发育期间α（2）-macroglobulin基因启动子的核定位和结合亲和力和急性期反应。

THE DNA BINDING AFFINITY OF RAT LIVER NUCLEOPROTEINS TO THE REGULATORY ELEMENTS OF THE HAPTOGLOBIN AND ALPHA(2)-MACROGLOBULIN GENES

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