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HYDROGEN PEROXIDE INDUCES MICROVILLI ON HUMAN RETINAL PIGMENT EPITHELIAL CELLS IN CULTURE

机译:过氧化氢诱导人视网膜色素上皮细胞微绒毛

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We have found that hydrogen peroxide (10(4) - 10(2) M) rapidly induces microvilli on separate cells and confluent sheets of human retinal pigment epithelium in culture. t-butyl hydroperoxide and sodium arsenite do not induce microvilli. A role for hydrogen peroxide as an intercellular messenger has previously been proposed in the inflammatory response, in which hydrogen peroxide from phagocytes may signal to vascular endothelial cells. Our observations thus provide a second example of the induction of what may be a physiological response by this potentially toxic agent. In the retina, hydrogen peroxide released from illuminated photoreceptors may elongate the microvilli which extend into the spaces between them. Increased numbers of microvilli and their protrusion further into the photoreceptor layer may enhance various interactions between the two cell types, including the antioxidant functions of the epithelium.
机译:我们发现过氧化氢(10(4)-10(2)M)在培养的人视网膜色素上皮细胞的单独细胞和融合片上迅速诱导微绒毛。叔丁基过氧化氢和亚砷酸钠不会引起微绒毛。先前已经提出过氧化氢作为细胞间信使的作用在炎症反应中,其中来自吞噬细胞的过氧化氢可以向血管内皮细胞发出信号。因此,我们的观察结果提供了第二种示例,说明这种潜在的毒性剂可能引起生理反应。在视网膜中,从受照感光体释放的过氧化氢可以拉长微绒毛,该绒毛延伸到它们之间的空间中。微绒毛数目的增加以及它们进一步伸入感光层的作用可以增强两种细胞类型之间的各种相互作用,包括上皮的抗氧化功能。

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