Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease

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Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease

机译：组织蛋白酶L和组织蛋白酶B在分泌小泡中的独特神经元功能：神经传递和神经退行性疾病中肽的生物合成

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Proteases are required for the production of peptide neurotransmitters and toxic peptides in neurodegenerative diseases. Unique roles of the cysteine proteases cathepsin L and cathepsin B in secretory vesicles for the production of biologically active peptides have been demonstrated in recent studies. Secretory vesicle cathepsin L participates in the proteolytic conversion of proenkephalin into the active enkephalin, an opioid peptide neurotransmitter that mediates pain relief. Moreover, recent findings provide evidence that cathepsin B in regulated secretory vesicles participates in the production of toxic beta-amyloid peptides that are known to accumulate extracellularly in Alzheimer's disease brains. The neurobiological functions of cathepsins L and B demonstrate that these secretory vesicle cysteine proteases produce biologically active peptides. These results demonstrate newly identified roles for cathepsins L and B in neurosecretory vesicles in the production of biologically active peptides.

机译：蛋白酶是神经退行性疾病中产生肽类神经递质和有毒肽所必需的。在最近的研究中已经证明了半胱氨酸蛋白酶组织蛋白酶L和组织蛋白酶B在分泌小泡中用于产生生物活性肽的独特作用。分泌性小泡组织蛋白酶L参与了前脑啡肽到活性脑啡肽的蛋白水解转化，这是一种能减轻疼痛的阿片类肽神经递质。此外，最近的发现提供了证据，即受调节的分泌小泡中的组织蛋白酶B参与了有毒的β-淀粉样蛋白肽的产生，已知该蛋白在细胞外积累在阿尔茨海默氏病的大脑中。组织蛋白酶L和B的神经生物学功能表明，这些分泌性囊泡半胱氨酸蛋白酶产生具有生物活性的肽。这些结果证明了组织蛋白酶L和B在神经分泌小泡中在生物活性肽生产中的新发现作用。

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《Biological chemistry》 |2006年第11期|共11页
作者
Hook VYH;
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正文语种 eng
中图分类生物化学;
关键词
beta-amyloid; cathepsin B; cathepsin L; enkephalin; neurodegenerative disease; neurology; peptide; peptide neurotransmission; secretory vesicles; AMYLOID PRECURSOR PROTEIN; CROSS-CLASS INHIBITION; LACKING PROHORMONE CONVERTASE-1; BETA-SECRETASE; ALZHEIMERS-DISEASE; PROCESSING ENZYME; CHROMAFFIN CELLS; CYSTEINE PROTEASES; NEUROPEPTIDE-Y; FULL-LENGTH;

机译：β-淀粉样蛋白;组织蛋白酶B;组织蛋白酶L;脑啡肽;神经退行性疾病;神经病学;肽;肽神经传递;分泌小泡;淀粉样前体蛋白;交叉类抑制;缺乏激素转换1-淀粉酶;ALZHE-酶;染色质细胞;半胱氨酸蛋白酶;神经肽-Y;全长;

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专利

1. Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease [J] . Hook VYH Biological chemistry . 2006,第10a11期

机译：组织蛋白酶L和组织蛋白酶B在分泌小泡中的独特神经元功能：神经传递和神经退行性疾病中肽的生物合成
2. Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides. [J] . Funkelstein L, Beinfeld M, Minokadeh A, Neuropeptides: An International Journal . 2010,第6期

机译：组织蛋白酶L在分泌小泡中对神经肽的生物合成的独特生物学功能。
3. Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. [J] . Hook V, Toneff T, Bogyo M, Biological chemistry . 2005,第9期

机译：组织蛋白酶B的抑制减少神经元嗜铬细胞的调节分泌囊泡中的β淀粉样蛋白的生产：组织蛋白酶B作为阿尔茨海默氏病候选β分泌酶的证据。
4. CONFORMATIONAL STUDIES OF SELECTED BENZYLSULPHONYLACROYL PEPTIDES - PUTATIVE INHIBITORS OF CATHEPSIN B [C] . Regina Kasprzykowska, Franciszek Kasprzykowski, Aleksandra S. Kolodziejczyk the European Peptide Symposium . 2007

机译：选定苄基磺酰基酰肽的构象研究 - 蛋白酶素诱导抑制剂B.
5. Increased stability of class II MHC-peptide complexes in macrophages infected with Mycobacterium avium and the examination of a novel role for cathepsin L in the innate immune response to Francisella novicida infection. [D] . Florence, William Clinton. 2007

机译：在鸟分枝杆菌感染的巨噬细胞中增加II类MHC肽复合物的稳定性，并检测组织蛋白酶L在对新生弗朗西斯菌感染的先天免疫应答中的新作用。
6. Cysteine Cathepsins in the Secretory Vesicle Produce Active Peptides: Cathepsin L Generates Peptide Neurotransmitters and Cathepsin B Produces Beta-Amyloid of Alzheimer’s Disease [O] . Vivian Hook, Lydiane Funkelstein, Jill Wegrzyn, -1

机译：分泌囊泡中的半胱氨酸组织蛋白酶产生活性肽：组织蛋白酶L产生肽神经递质和组织蛋白酶B产生阿尔茨海默病的β-淀粉样蛋白
7. Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides [O] . Lydiane Funkelstein, Margery Beinfeld, Ardalan Minokadeh, 2010

机译：组织蛋白酶L中的独特生物功能，用于神经肽生物合成的分泌囊泡

Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease

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