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首页> 外文期刊>Cell biology international. >Distribution of EGF and its receptor in growing red deer antler.
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Distribution of EGF and its receptor in growing red deer antler.

机译：EGF及其受体在马鹿茸生长中的分布。

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Autografts of the osteogenic part of early antler buds placed elsewhere on the skull have been shown by others to give rise to an antler at the site of grafting. This antler becomes covered in velvet skin, is shed at the end of the growing season and will regrow the following year. Thus, it can be concluded that the nature of antler velvet skin is primarily determined by the underlying osteogenic antler tissue to which it is attached. We hypothesise that a paracrine mechanism operates here and is central to communication between the antler osseous compartment and the integument. A signalling system comprising epidermal growth factor (EGF) and its receptor (EGFR) is known to be expressed in osteogenic cells and to play an important role in skin development and growth. This system may therefore play a significant role in determining the nature and speed of growth of velvet skin via paracrine signalling from osteogenic tissue. We have used bright-field microscope immunohistochemistry to determine the distribution of EGF and its receptor in developing red deer antler osseous compartment and integument. EGF was localized throughout the epidermis and epidermal appendages, in cells of the mesenchyme, in chondrocytes, and in cells of the osteoblastic lineage, including osteoprogenitor cells, osteoblasts and osteocytes. There was strong evidence supporting nuclear and nucleolar staining in sebaceous glands and in keratinocytes. The EGFR was similarly expressed in mesenchyme, chondrocytes and osteoblasts. In skin, the distribution of the EGFR was more localized, being expressed strongly in the deeper cells of the epidermis but not in superficial layers, and was absent from nuclei of cells of the epidermis and its appendages. We conclude that this signalling system is widely distributed in growing antler in a manner which suggests it is predominantly autocrine. No clear-cut evidence for paracrine signalling pathways for this system in either integument or osseous compartments was found. The pattern of distribution of the EGFR in the integument was similar to that seen by others in adult human skin. By contrast, in developing antler osseocartilage, the patterns of distribution were similar to those seen in rodent fetal bone. We conclude that antler consists of rapidly growing fetal osseocartilage overlayed by mature velvet.
机译：其他人已证明，将自体的早期鹿角芽的成骨部分移植到颅骨的其他部位会在移植部位产生鹿角。这种鹿角被天鹅绒皮覆盖，在生长季节结束时脱落，并在第二年重新生长。因此，可以得出结论，鹿茸皮的性质主要由其所附着的潜在成骨鹿茸组织决定。我们假设旁分泌机制在这里起作用，并且是鹿角骨腔室和外皮之间通讯的核心。已知包含表皮生长因子（EGF）及其受体（EGFR）的信号系统在成骨细胞中表达，并在皮肤发育和生长中起重要作用。因此，该系统在通过成骨组织的旁分泌信号传导确定天鹅绒皮肤的生长性质和速度方面可能起重要作用。我们已使用明场显微镜免疫组织化学来确定EGF及其受体在马鹿茸骨隔室和被膜中的分布。 EGF位于整个表皮和表皮附肢，间充质细胞，软骨细胞和成骨细胞谱系的细胞中，包括成骨祖细胞，成骨细胞和成骨细胞。有强有力的证据支持皮脂腺和角质形成细胞中的核和核仁染色。 EGFR在间充质，软骨细胞和成骨细胞中表达相似。在皮肤中，EGFR的分布更为局限，在表皮的较深细胞中强烈表达，而在表层则不表达，并且在表皮及其附属细胞的细胞核中不存在。我们得出结论，该信号系统以一种表明其主要是自分泌的方式广泛分布于鹿茸中。在皮被或骨隔室中均未发现该系统旁分泌信号通路的明确证据。 EGFR在被膜中的分布模式与成人皮肤中其他人所见的相似。相比之下，在发育的鹿角骨软骨中，分布模式与在啮齿动物胎儿骨骼中看到的分布模式相似。我们得出的结论是，鹿角由迅速生长的胎儿骨软骨覆盖，并覆盖有成熟的天鹅绒。

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