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首页> 外文期刊>Cell biology international. >Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer.
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Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer.

机译：胡芦巴（胡芦巴）对乳腺癌的化学预防活性。

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摘要

Cancer is the second leading cause of death worldwide. Conventional therapies cause serious side effects and, at best, merely extend the patient's lifespan by a few years. Cancer control may therefore benefit from the potential that resides in alternative therapies. There is thus an increasing demand to utilize alternative concepts or approaches to the prevention of cancer. In this report, we show a potential protective effect of Fenugreek seeds against 7,12-dimethylbenz(alpha)anthracene (DMBA)-induced breast cancer in rats. At 200 mg/kg b.wt., Fenugreek seeds' extract significantly inhibited the DMBA-induced mammary hyperplasia and decreased its incidence. Epidemiological studies also implicate apoptosis as a mechanism that might mediate the Fenugreek's anti-breast cancer protective effects. To our knowledge, this is the first study that suggests significant chemopreventive effects of Fenugreek seeds against breast cancer.
机译：癌症是全球第二大死亡原因。常规疗法会引起严重的副作用，充其量只能将患者的寿命延长数年。因此，癌症控制可能会受益于替代疗法的潜力。因此，越来越需要利用替代概念或方法来预防癌症。在此报告中，我们显示胡芦巴种子对大鼠7,12-二甲基苯并α-蒽（DMBA）诱导的乳腺癌的潜在保护作用。胡芦巴种子的提取物以200 mg / kg b.wt.的浓度显着抑制DMBA诱导的乳腺增生并降低其发生率。流行病学研究还暗示凋亡是一种可能介导胡芦巴抗乳腺癌保护作用的机制。据我们所知，这是第一项表明胡芦巴种子对乳腺癌具有显着化学预防作用的研究。

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