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首页> 外文期刊>Cell biology international. >Rab11 is essential for fertility in Drosophila.
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Rab11 is essential for fertility in Drosophila.

机译：Rab11对果蝇的繁殖至关重要。

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摘要

Rab11, a small GTP binding protein involved in vesicular trafficking, has emerged as a key player in regulating various cellular events during Drosophila development and differentiation. In our earlier study a P-insertion line, Rab11mo, was established as a new hypomorphic allele of Rab11 gene, showing degenerated eye phenotype, bristle abnormalities and sterility. We show here that Rab11 is expressed in the entire testis, more prominently in the secretory cells, and in ovary it is localized at the posterior pole. Rab11mo males and females are sterile. The sterility in males has been attributed to defects in the sperm individualization process, while in females, cytoskeleton disruption and reduction/loss of the posteriorly localized protein, Vasa, as a consequence of loss/mislocalization of Rab11 might be the cause of sterility. Fertility as well as the posterior localization of Rab11 and Vasa or cytoskeleton integrity was restored in pCaSpeR4-Rab11/+; Rab11mo/Rab11mo egg chambers, confirming the requirement of Rab11 in these events.
机译：Rab11，一种参与水泡运输的小GTP结合蛋白，已经成为果蝇发育和分化过程中调节各种细胞事件的关键参与者。在我们较早的研究中，P插入系Rab11mo被确定为Rab11基因的一个新的亚等位基因，表现出退化的眼表型，刷毛异常和不育。我们在这里显示，Rab11在整个睾丸中表达，在分泌细胞中更显着，在卵巢中它位于后极。 Rab11mo的雄性和雌性都是不育的。雄性不育归因于精子个体化过程中的缺陷，而雌性中，由于Rab11丢失/定位不当的结果，细胞骨架破坏和后定位蛋白Vasa的减少/丢失可能是不育的原因。 pCaSpeR4-Rab11 / +恢复了Rab11和Vasa的生育能力以及后定位或细胞骨架完整性。 Rab11mo / Rab11mo蛋腔，确认了在这些事件中对Rab11的需求。

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