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首页> 外文期刊>Cell biology international. >The human megakaryocytic cell line UT-7/TPO responds to platelet agonists with intracellular Ca2+ elevation and P-selectin expression.
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The human megakaryocytic cell line UT-7/TPO responds to platelet agonists with intracellular Ca2+ elevation and P-selectin expression.

机译：人巨核细胞系UT-7 / TPO对血小板激动剂的反应是细胞内Ca2 +升高和P-选择蛋白表达。

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摘要

Megakaryocytes have several signal transduction cascades that are similar, but not identical to platelet activation signals. In order to understand platelet signals in detail, it is useful to compare the similarities and/or differences between platelets and megakaryocytes. We evaluated platelet activation signals related to three kinds of Gq protein-coupled receptors using the megakaryocytic cell line UT-7/TPO. It was found that UT-7/TPO responded to thrombin, resulting in a continuous elevation of the [Ca2+]i (intracellular Ca2+) and P-selectin expression on the surface of the cells. Activation of integrin alphaIIbbeta3 and thromboxane generation was not detected by any of the three stimulations. Taken together, although strong [Ca2+]i elevation by thrombin stimulation caused further P-selection expression, we could detect [Ca2+]i elevation, which is thought to be the individual signals through the thrombin, thromboxane A2 or ADP receptor, without considering the secondary signalling caused by alphaIIbbeta3 activation and the arachidonic acid cascade using UT-7/TPO.
机译：巨核细胞具有几个相似但与血小板活化信号不同的信号转导级联。为了详细了解血小板信号，比较血小板和巨核细胞之间的相似性和/或差异是有用的。我们使用巨核细胞系UT-7 / TPO评估了与三种Gq蛋白偶联受体相关的血小板活化信号。发现UT-7 / TPO对凝血酶有反应，导致[Ca2 +] i（细胞内Ca2 +）和P-选择蛋白在细胞表面的表达持续升高。三种刺激均未检测到整合素alphaIIbbeta3的激活和血栓烷的生成。综上所述，尽管凝血酶刺激导致[Ca2 +] i升高，进而导致P选择表达，但我们可以检测到[Ca2 +] i升高，这被认为是通过凝血酶，凝血酶A2或ADP受体的单个信号，而无需考虑alphaIIbbeta3激活和使用UT-7 / TPO的花生四烯酸级联引起的次级信号传导。

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