...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell and Tissue Research >Src-signaling interference impairs the dissemination of blood-borne tumor cells.
【24h】

Src-signaling interference impairs the dissemination of blood-borne tumor cells.

机译：Src信号干扰削弱了血源性肿瘤细胞的传播。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although solid tumors continuously shed cells, only a small fraction of the neoplastic cells that enter the blood stream are capable of establishing metastases. In order to be successful, these cells must attach, extravasate, proliferate and induce angiogenesis. Preclinical studies have shown that small-molecule ATP-competitive Src kinase inhibitors can effectively impair metastasis-associated tumor cell functions in vitro. However, the impact of these agents on the metastatic cascade in vivo is less well understood. In the present studies, we have examined the ability of saracatinib, a dual-specific, orally available inhibitor of Src and Abl protein tyrosine kinases, to interfere with the establishment of lung metastases in mice by tumor cells introduced into the blood stream. The results demonstrate that Src inhibition most effectively interferes with the establishment of secondary tumor deposits when treatments are administered while tumor cells are in the initial phases of dissemination.
机译：尽管实体瘤不断脱落细胞，但只有一小部分进入血流的肿瘤细胞能够转移。为了获得成功，这些细胞必须附着，渗出，增殖并诱导血管生成。临床前研究表明，小分子ATP竞争性Src激酶抑制剂可在体外有效削弱与转移相关的肿瘤细胞功能。然而，这些试剂对体内转移级联的影响尚不十分清楚。在本研究中，我们研究了萨拉卡替尼（一种双重特异性，口服可利用的Src和Abl蛋白酪氨酸激酶抑制剂）通过引入血流中的肿瘤细胞干扰小鼠肺部转移的能力。结果表明，当肿瘤细胞处于传播的初始阶段进行治疗时，Src抑制最有效地干扰了继发性肿瘤沉积物的建立。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号