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首页> 外文期刊>NMR in biomedicine >MR-based measurements and simulations of the magnetic field created by a realistic transcranial magnetic stimulation (TMS) coil and stimulator
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MR-based measurements and simulations of the magnetic field created by a realistic transcranial magnetic stimulation (TMS) coil and stimulator

机译：现实的经颅磁刺激（TMS）线圈和刺激器产生的基于MR的磁场测量和模拟

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摘要

Transcranial magnetic stimulation (TMS) is an emerging technique that allows non-invasive neurostimulation. However, the correct validation of electromagnetic models of typical TMS coils and the correct assessment of the incident TMS field (B-TMS) produced by standard TMS stimulators are still lacking. Such a validation can be performed by mapping B-TMS produced by a realistic TMS setup. In this study, we show that MRI can provide precise quantification of the magnetic field produced by a realistic TMS coil and a clinically used TMS stimulator in the region in which neurostimulation occurs. Measurements of the phase accumulation created by TMS pulses applied during a tailored MR sequence were performed in a phantom. Dedicated hardware was developed to synchronize a typical, clinically used, TMS setup with a 3-T MR scanner. For comparison purposes, electromagnetic simulations of B-TMS were performed. MR-based measurements allow the mapping and quantification of B-TMS starting 2.5cm from the TMS coil. For closer regions, the intra-voxel dephasing induced by B-TMS prohibits TMS field measurements. For 1% TMS output, the maximum measured value was similar to 0.1 mT. Simulations reflect quantitatively the experimental data. These measurements can be used to validate electromagnetic models of TMS coils, to guide TMS coil positioning, and for dosimetry and quality assessment of concurrent TMS-MRI studies without the need for crude methods, such as motor threshold, for stimulation dose determination.
机译：经颅磁刺激（TMS）是一种新兴技术，可实现非侵入性神经刺激。但是，仍然缺乏对典型TMS线圈电磁模型的正确验证以及对标准TMS激励器产生的入射TMS磁场（B-TMS）的正确评估。可以通过映射由实际TMS设置产生的B-TMS来执行这种验证。在这项研究中，我们表明MRI可以精确量化由真实TMS线圈和在发生神经刺激的区域中临床使用的TMS刺激器产生的磁场。在幻像中对在定制MR序列期间施加的TMS脉冲产生的相位积累进行了测量。开发了专用硬件，以使典型的临床使用的TMS设置与3-T MR扫描仪同步。为了进行比较，对B-TMS进行了电磁仿真。基于MR的测量允许对距TMS线圈2.5cm处的B-TMS进行映射和量化。对于较近的区域，由B-TMS引起的体素内移相会禁止TMS现场测量。对于1％TMS输出，最大测量值类似于0.1 mT。仿真定量地反映了实验数据。这些测量可用于验证TMS线圈的电磁模型，指导TMS线圈的定位，以及用于同时进行TMS-MRI研究的剂量学和质量评估，而无需使用刺激性的方法来确定刺激剂量，例如运动阈值。

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