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首页> 外文期刊>Cell motility and the cytoskeleton >The effects of collapsing factors on F-actin content and microtubule distribution of Helisoma growth cones.
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The effects of collapsing factors on F-actin content and microtubule distribution of Helisoma growth cones.

机译：崩溃因素对Helisoma生长锥的F-肌动蛋白含量和微管分布的影响。

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Growth cone collapsing factors induce growth cone collapse or repulsive growth cone turning by interacting with membrane receptors that induce alterations in the growth cone cytoskeleton. A common change induced by collapsing factors in the cytoskeleton of the peripheral domain, the thin lamellopodial area of growth cones, is a decline in the number of radially aligned F-actin bundles that form the core of filopodia. The present study examined whether ML-7, a myosin light chain kinase inhibitor, serotonin, a neurotransmitter and TPA, an activator of protein kinase C, which induce growth cone collapse of Helisoma growth cones, depolymerized or debundled F-actin. We report that these collapsing factors had different effects. ML-7 induced F-actin reorganization consistent with debundling whereas serotonin and TPA predominately depolymerized and possibly debundled F-actin. Additionally, these collapsing factors induced the formation of a dense actin-ring around the central domain, the thicker proximal areaof growth cones [Zhou and Cohan, 2001: J. Cell Biol. 153:1071-1083]. The formation of the actin-ring occurred subsequent to the loss of actin bundles. The ML-7-induced actin-ring was found to inhibit microtubule extension into the P-domain. Thus, ML-7, serotonin, and TPA induce growth cone collapse associated with a decline in radially aligned F-actin bundles through at least two mechanisms involving debundling of actin filaments and/or actin depolymerization. Cell Motil. Cytoskeleton 60:166-179, 2005. (c) 2005 Wiley-Liss, Inc.
机译：生长锥塌陷因子通过与诱导生长锥细胞骨架改变的膜受体相互作用，诱导生长锥塌陷或排斥性生长锥翻转。由周围区域的细胞骨架（生长锥的薄椎板区域）中的塌陷因子引起的常见变化是形成丝状伪足核心的径向排列的F-肌动蛋白束的数量下降。本研究检查了肌球蛋白轻链激酶抑制剂ML-7，神经递质5-羟色胺和蛋白激酶C的活化剂TPA是否引起Helisoma生长锥的生长锥塌陷，F-肌动蛋白解聚或解聚。我们报告这些崩溃因素具有不同的影响。 ML-7诱导的F-肌动蛋白重组与去捆绑一致，而5-羟色胺和TPA则主要是解聚，甚至可能是去捆绑的F-肌动蛋白。另外，这些塌缩因子诱导在中心区域周围较厚的生长锥近端区域周围形成致密的肌动蛋白环[Zhou和Cohan，2001：J.Cell Biol.Chem。，2001，44，2105]。 153：1071-1083]。肌动蛋白环的形成发生在肌动蛋白束丢失之后。发现ML-7诱导的肌动蛋白环抑制微管延伸到P结构域。因此，ML-7、5-羟色胺和TPA通过至少两种涉及肌动蛋白丝解开和/或肌动蛋白解聚的机制，导致与径向排列的F-肌动蛋白束下降相关的生长锥塌陷。细胞动力。 Cytoskeleton 60：166-179，2005.（c）2005 Wiley-Liss，Inc.

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