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首页> 外文期刊>Cell motility and the cytoskeleton >Dynamic organization of microtubules and microtubule-organizing centers during the sexual phase of a parasitic protozoan, Lecudina tuzetae (Gregarine, Apicomplexa).
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Dynamic organization of microtubules and microtubule-organizing centers during the sexual phase of a parasitic protozoan, Lecudina tuzetae (Gregarine, Apicomplexa).

机译：在寄生原生动物Lecudina tuzetae（Gregarine，Apicomplexa）的性生活阶段，微管和微管组织中心的动态组织。

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摘要

Lecudina tuzetae is a parasitic protozoan (Gregarine, Apicomplexa) living in the intestine of a marine polychaete annelid, Nereis diversicolor. Using electron and fluorescence microscopy, we have characterized the dynamic changes in microtubule organization during the sexual phase of the life cycle. The gametocyst excreted from the host worm into seawater consists of two (one male and one female) gamonts in which cortical microtubule arrays are discernible. Each gamont undergoes multiple nuclear divisions without cytokinesis, resulting in the formation of large multinucleate haploid cells. After cellularization, approximately 1000 individual gametes are produced from each gamont within 24 h. Female gametes are spherical and contain interphase cytoplasmic microtubule arrays emanating from a gamma-tubulin-containing site. In male gametes, both interphase microtubules and a flagellum with "6 + 0" axonemal microtubules extend from the same microtubule-organizing site. At the beginning of spore formation, each zygote secretes a wall to form a sporocyst. Following meiotic and mitotic divisions, each sporocyst gives rise to eight haploid cells that ultimately differentiate into sporozoites. The ovoid shaped sporocyst is asymmetric and forms at least two distinctive microtubule arrays: spindle microtubules and microtubule bundles originating from the protruding apical end corresponding to the dehiscence pole of the sporocyst. Because antibodies raised against mammalian centrosome components, such as gamma-tubulin, pericentrin, Cep135, and mitosis-specific phosphoproteins, react strongly with the microtubule-nucleating sites of Lecudina, this protozoan is likely to share common centrosomal antigens with higher eukaryotes.
机译：Lecudina tuzetae是生活在海洋多毛小轮虫（Nereis diversicolor）的肠内的寄生原生动物（Gregarine，Apicomplexa）。使用电子和荧光显微镜，我们表征了生命周期性阶段微管组织的动态变化。从宿主蠕虫排泄到海水中的配子囊由两个（一个雄性和一个一个雌性）gamont组成，在其中可见皮质微管阵列。每个gamont都会经历多个核分裂而没有胞质分裂，从而形成大型多核单倍体细胞。细胞化后，在24小时内从每个gamont产生大约1000个单独的配子。雌配子是球形的，并且包含从含γ-微管蛋白的部位发出的相间胞质微管阵列。在雄性配子中，相间微管和带有“ 6 + 0”轴突微管的鞭毛都从相同的微管组织位点延伸。在孢子形成开始时，每个合子都会分泌壁以形成孢子囊。在减数分裂和有丝分裂分裂之后，每个孢子囊都会产生八个单倍体细胞，最终分化为子孢子。卵形孢子囊是不对称的，并形成至少两个独特的微管阵列：纺锤体微管和微管束，其起源于与孢子囊裂开极对应的突出的顶端。由于针对哺乳动物中心体成分（例如，γ-微管蛋白，pericentrin，Cep135和有丝分裂特异性磷蛋白）产生的抗体会与Lecudina的微管成核位点强烈反应，因此这种原生动物很可能与较高等的真核生物共享常见的中心体抗原。

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