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首页> 外文期刊>Caries research >Caries-preventive effect of chlorhexidine gel applications among high-risk children.
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Caries-preventive effect of chlorhexidine gel applications among high-risk children.

机译：洗必太凝胶在高危儿童中的预防龋齿作用。

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Evidence on the caries-preventive effect of chlorhexidine (CHX) among high-risk children is inconclusive, possibly because obscured by fluoride exposure. We investigated the effect of CHX among initially 3-year-old subjects whose baseline d(3)ft was = 0 and whose only regular fluoride exposure came from toothpaste. The subjects were assigned to three groups: high-risk test (HRT, n = 70), high-risk control (HRC, n = 71), and low-risk control (LRC, n = 70). Risk classification was based on salivary mutans streptococcal levels (MS, or=1.0 x 10(5) cfu/ml). Basic measures (oral hygiene, dietary counselling every 4 months) were given to all groups. HRT also underwent CHX gel applications for 3 consecutive days at 3-month intervals for 15 months. Eighteen months after baseline d(3)ft increments and proportions of children with d(3)ft increment >or=1 (%d(3)ft increment >or=1) among all groups were assessed. Anti-MS effect on high-risk children and caries-preventive effect on all children were statistically analysed by residual change analysis (MS), non-parametric tests and logistic regression analysis (caries). No differences were found between the groups in basic programme compliance. CHX significantly reduced MS levels. %d(3)ft increment >or=1 and mean d(3)ft increments were 34.3%, 0.56 (HRT), 32.4%, 0.54 (HRC) and 11.4%, 0.11 (LRC), with HRT/HRC values statistically significantly higher than LRC values and no significant difference between HRT and HRC. HRT children were not less likely to show new lesions than HRC children (OR = 1.09; 95% confidence interval 0.54-2.19), while high-risk children were 4 times more likely to show new lesions than low-risk children (OR = 3.71; 95% confidence interval 1.53-9.03). CHX gel applications showed moderate anti-MS effect but negligible caries-preventive effect.
机译：高风险儿童中洗必泰（CHX）防龋效果的证据尚无定论，这可能是由于暴露于氟化物所致。我们调查了CHX对最初的3岁受试者的基线d（3）ft = 0且仅有定期的氟化物暴露来自牙膏的影响。将受试者分为三组：高风险测试（HRT，n = 70），高风险控制（HRC，n = 71）和低风险控制（LRC，n = 70）。风险分类基于唾液变异链球菌水平（MS，<或= 1.0 x 10（5）cfu / ml）。所有组均采取基本措施（口腔卫生，每四个月进行饮食咨询）。 HRT还连续3天以3个月为间隔连续15天进行CHX凝胶应用。评估基线d（3）ft增量后18个月以及所有组中d（3）ft增量>或= 1（％d（3）ft增量>或= 1）的儿童的比例。通过残差变化分析（MS），非参数检验和逻辑回归分析（龋齿），对高危儿童的抗MS作用和对所有患儿的龋齿预防作用进行了统计分析。两组之间在基本计划合规性方面没有发现差异。 CHX显着降低了MS水平。 ％d（3）ft增量>或= 1，平均d（3）ft增量为34.3％，0.56（HRT），32.4％，0.54（HRC）和11.4％，0.11（LRC），HRT / HRC值统计显着高于LRC值，HRT和HRC之间无显着差异。 HRT儿童出现新病变的可能性不低于HRC儿童（OR = 1.09; 95％置信区间0.54-2.19），而高风险儿童出现新病变的可能性是低风险儿童的4倍（OR = 3.71） ; 95％置信区间1.53-9.03）。 CHX凝胶应用显示出中等的抗MS效果，但防龋效果却可忽略不计。

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