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Food Protein Fragments Are Regulatory Oligopeptides

机译：食物蛋白片段是调节性寡肽

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摘要

Until recently food proteins were considered to be an energy source and a source of essential and nonessential amino acids required for protein synthesis and precursors of many vital biomolecules. However, we assumed earlier that food protein fragments might perform some regulatory functions. The theoretical justification for this assumption is advanced in this work. In the present work, the primary structures of protein fragments were compared with amino acid sequences of known natural regulatory oligopeptides in silico. It is shown that fragments formed as a result of animal food protein cleavage by proteolytic enzymes can exist in the gastrointestinal tract for a long time. Many of them are enzyme inhibitors, regulators of nervous, endocrine, and immune system, and possess antimicrobial and other activities. It has also been shown that the lifetime of fragments before their cleavage in the gastrointestinal tract could be enough for performing corrective functions. Thus, as a result of food protein fragmentation a dynamic pool of exogenous regulatory oligopeptides with functions changing as shorter fragments are generated may form. The detection of an endogenous-exogenous pool of regulatory molecules expands the significance and content of the Ashmarin-Obukhova hypothesis on a functional continuum of natural oligopeptides. The possible practical importance of these resuhs is noted.
机译：直到最近，人们还认为食物蛋白是蛋白质合成和许多重要生物分子的前体所必需的能量来源和必需氨基酸和非必需氨基酸。但是，我们较早地假设食物蛋白片段可能具有某些调节功能。该假设的理论依据在这项工作中得到了发展。在目前的工作中，将蛋白质片段的一级结构与已知的计算机天然调控寡肽的氨基酸序列进行了比较。已经表明，由于蛋白水解酶对动物食物蛋白的切割而形成的片段可以在胃肠道中长期存在。它们中的许多是酶抑制剂，神经，内分泌和免疫系统的调节剂，并具有抗菌和其他活性。还已经表明，片段在胃肠道中裂解之前的寿命可能足以执行校正功能。因此，由于食物蛋白质片段化，可形成外源调节寡肽的动态库，其功能随着生成的较短片段而改变。内源性-外源性调节分子库的检测扩展了天然寡肽功能连续体上的Ashmarin-Obukhova假设的意义和内容。这些结果可能具有实际意义。

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