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Ribosomal Proteins: Structure, Function, and Evolution

机译：核糖体蛋白：结构，功能和进化

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摘要

The question concerning reasons for the variety of ribosomal proteins that arose for more than 40 years ago is still open. Ribosomes of modern organisms contain 50-80 individual proteins. Some are characteristic for all domains of life (universal ribosomal proteins), whereas others are specific for bacteria, archaea, or eucaryotes. Extensive information about ribosomal proteins has been obtained since that time. However, the role of the majority of ribosomal proteins in the formation and functioning of the ribosome is still not so clear. Based on recent data of experiments and bioinformatics, this review presents a comprehensive evaluation of structural conservatism of ribosomal proteins from evolutionarily distant organisms. Considering the current knowledge about features of the structural organization of the universal proteins and their inter-molecular contacts, a possible role of individual proteins and their structural elements in the formation and functioning of ribosomes is discussed. The structural and functional conservatism of the majority of proteins of this group suggests that they should be present in the ribosome already in the early stages of its evolution.
机译：关于40年前出现的核糖体蛋白变异原因的问题仍然悬而未决。现代生物的核糖体包含50-80个单独的蛋白质。有些具有生命的所有领域（通用的核糖体蛋白）的特征，而另一些则具有细菌，古细菌或真核生物的特异性。从那时起已经获得了有关核糖体蛋白的广泛信息。但是，大多数核糖体蛋白在核糖体的形成和功能中的作用仍不清楚。基于实验和生物信息学的最新数据，本综述对进化距离远的生物体的核糖体蛋白的结构保守性进行了全面评估。考虑到有关通用蛋白质的结构组织及其分子间接触特征的当前知识，讨论了单个蛋白质及其结构元素在核糖体形成和功能中的可能作用。该组大多数蛋白质的结构和功能保守性表明，它们应在其进化的早期就已经存在于核糖体中。

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