Src homology 2 domain of overexpressed Lyn kinase is responsible for the acceleration of granulocyte colony-stimulating factor-induced neutrophilic nuclear lobulation.

Oka N; Suzuki A; Omura T; Sakai H; Murakami H

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Src homology 2 domain of overexpressed Lyn kinase is responsible for the acceleration of granulocyte colony-stimulating factor-induced neutrophilic nuclear lobulation.

机译：过表达的Lyn激酶的Src同源2域负责加速粒细胞集落刺激因子诱导的中性粒细胞核叶形成。

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We have previously shown that the overexpression of a Src family kinase, Lyn, and its kinase-negative form, LynKN, in a granulocyte progenitor cell line, GM-I62M, accelerates neutrophilic nuclear lobulation when the cells are cultured in the presence of granulocyte colony-stimulating factor. In this study, we investigated the role of the Src homology 2 (SH2) and SH3 domains of Lyn in the accelerated induction of nuclear lobulation. In contrast to wild-type Lyn, the overexpression of its SH2 domain mutant did not induce the accelerated nuclear morphological changes, but the overexpressed SH3 domain mutant had the same effects as wild-type Lyn. Therefore, the SH2 domain of Lyn is responsible for the accelerated induction of neutrophilic nuclear lobulation upon G-CSF stimulation.

机译：先前我们已经表明，当在粒细胞集落的存在下培养细胞时，粒细胞祖细胞系GM-I62M中Src家族激酶Lyn及其激酶阴性形式LynKN的过表达会加速嗜中性细胞核的成叶。 -刺激因子。在这项研究中，我们调查了Lyn的Src同源2（SH2）和SH3域在加速诱导核小叶形成中的作用。与野生型Lyn相比，其SH2结构域突变体的过表达不会诱导加速的核形态变化，但过表达的SH3域突变体与野生型Lyn具有相同的作用。因此，Lyn的SH2域负责在G-CSF刺激后加速诱导嗜中性核小叶的形成。

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《Cell biology international.》 |2006年第6期|共8页
作者
Oka N; Suzuki A; Omura T; Sakai H; Murakami H;
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正文语种 eng
中图分类细胞生物学;
关键词
overexpress; Granulocyte Colony-Stimulating Factor; Phosphotransferases; 粒细胞集落刺激因子; 磷酸转移酶类; 离子;

机译：overexpress;Granulocyte Colony-Stimulating Factor;Phosphotransferases;粒细胞集落刺激因子;磷酸转移酶类;离子;

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1. Src homology 2 domain of overexpressed Lyn kinase is responsible for the acceleration of granulocyte colony-stimulating factor-induced neutrophilic nuclear lobulation. [J] . Oka N, Suzuki A, Omura T, Cell biology international. . 2006,第6期

机译：过表达的Lyn激酶的Src同源2域负责加速粒细胞集落刺激因子诱导的中性粒细胞核叶形成。
2. p66shc Inhibits Insulin-like Growth Factor-I Signaling via Direct Binding to Src through Its Polyproline and Src Homology 2 Domains, Resulting in Impairment of Src Kinase Activation [J] . Gang Xi, Xinchun Shen, David R. Clemmons The Journal of biological chemistry . 2010,第10期

机译：P66SHC通过其聚丙烯和SRC同源2结构域通过直接结合SRC抑制胰岛素样生长因子-i信号传导，导致SRC激酶活化的损伤
3. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colony-stimulating factor/IL-5 receptor. [J] . Adachi T, Pazdrak K, Stafford S, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第3期

机译：IL-3 /粒细胞-巨噬细胞集落刺激因子/ IL-5受体共同β亚基的Lyn激酶结合位点的图谱。
4. Binding of Brutons tyrosine kinase to Fyn Lyn or Hck through a Src homology 3 domain-mediated interaction. [O] . G Cheng, Z S Ye, D Baltimore 1994

机译：通过Src同源性3域介导的相互作用将布鲁顿酪氨酸激酶与FynLyn或Hck结合。
5. Acceleration of granulocyte colony-stimulating factor-induced neutrophilic nuclear lobulation by overexpression of Lyn tyrosine kinase [O] . Tomomi Omura, Hiroshi Sakai, Hiroshi Murakami 2002

机译：通过过表达Lyn酪氨酸激酶过表达加速粒细胞菌落刺激因子诱导的中性粒核裂解

Src homology 2 domain of overexpressed Lyn kinase is responsible for the acceleration of granulocyte colony-stimulating factor-induced neutrophilic nuclear lobulation.

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