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首页> 外文期刊>Cell biology international. >Glucocorticoids enhance serum deprivation- but not calcium-induced cytotoxicity in rat C6 glioma cells.
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Glucocorticoids enhance serum deprivation- but not calcium-induced cytotoxicity in rat C6 glioma cells.

机译：糖皮质激素增强大鼠C6胶质瘤细胞的血清剥夺，但不增强钙诱导的细胞毒性。

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摘要

While glucocorticoids have been shown to exacerbate calcium-induced neuronal damage, little is known about the effects of these hormones on calcium-induced damage to glial cells. Here we examine the effect of synthetic glucocorticoid dexamethasone on calcium ionophore A23187 and serum deprivation-induced damage to rat C6 glioma cells. Treatment of the glioma cells with A23187 reduced cell viability, similar in extent to that observed with serum deprivation. Both A23187 and serum deprivation caused cell damage without degradation of the genomic DNA into nucleosomic fragments. In addition, the reduction in cell viability caused by A23187 was not significantly altered by DEX at concentrations enhancing serum deprivation-induced cell death. These results suggest that the cytotoxic effect of A23187 on glial cells may be mediated through a mechanism different from that underlying serum deprivation-induced cell death, and that, in contrast to calcium-induced neuronal damage, calcium-induced damage to glial cells is likely to be insensitive to glucocorticoids. Copyright 2000 Academic Press.
机译：虽然已经显示糖皮质激素会加剧钙诱导的神经元损伤，但对于这些激素对钙诱导的神经胶质细胞损伤的作用知之甚少。在这里，我们检查了合成的糖皮质激素地塞米松对钙离子载体A23187和血清剥夺诱导的对大鼠C6胶质瘤细胞的损害的作用。用A23187处理神经胶质瘤细胞降低了细胞活力，其程度与血清剥夺观察到的相似。 A23187和血清剥夺都引起细胞损伤，而基因组DNA不降解成核小片段。另外，在增强血清剥夺诱导的细胞死亡的浓度下，DEX并没有明显改变由A23187引起的细胞活力的降低。这些结果表明，A23187对神经胶质细胞的细胞毒性作用可能是通过与潜在的血清剥夺诱导的细胞死亡不同的机制来介导的，并且与钙诱导的神经元损害相反，钙诱导的对神经胶质细胞的损害可能对糖皮质激素不敏感。版权所有2000学术出版社。

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