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Endogenous musculoskeletal tissue engineering - A focused perspective

机译:内源性肌肉骨骼组织工程-聚焦视角

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摘要

Two major difficulties facing widespread clinical implementation of existing Tissue Engineering (TE) strategies for the treatment of musculoskeletal disorders are (1) the cost, space and time required for ex vivo culture of a patient's autologous cells prior to re-implantation as part of a TE construct, and (2) the potential risks and availability constraints associated with transplanting exogenous (foreign) cells. These hurdles have led to recent interest in endogenous TE strategies, in which the regenerative potential of a patient's own cells is harnessed to promote tissue regrowth without ex vivo cell culture. This article provides a focused perspective on key issues in the development of endogenous TE strategies, progress to date, and suggested future research directions toward endogenous repair and regeneration of musculoskeletal tissues and organs.
机译:现有的组织工程(TE)策略用于治疗肌肉骨骼疾病的广泛临床实施面临的两个主要困难是(1)在将患者的自体细胞作为器官移植的一部分重新植入之前进行离体培养所需的成本,空间和时间。 TE构建,以及(2)与移植外源(外来)细胞相关的潜在风险和可用性限制。这些障碍引起了对内源性TE策略的最新兴趣,在这种策略中,可以利用患者自身细胞的再生潜能来促进组织再生,而无需进行离体细胞培养。本文就内源性TE策略的发展中的关键问题,迄今为止的进展提供了集中的观点,并提出了对肌肉骨骼组织和器官进行内源性修复和再生的未来研究方向。

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