...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis >Amerindian genetic ancestry and INDEL polymorphisms associated with susceptibility of childhood B-cell Leukemia in an admixed population from the Brazilian Amazon
【24h】

Amerindian genetic ancestry and INDEL polymorphisms associated with susceptibility of childhood B-cell Leukemia in an admixed population from the Brazilian Amazon

机译：与来自巴西亚马逊河混血儿的儿童B细胞白血病易感性相关的美洲印第安人遗传学和INDEL多态性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Acute lymphoblastic leukemia (ALL) is a malignant tumor common in children. Studies of genetic susceptibility to cancer using biallelic insertion/deletion (INDEL) type polymorphisms associated with cancer development pathways may help to clarify etymology of ALL. In this study, we investigate the role of eight functional INDEL polymorphisms and influence of genetic ancestry to B-cell ALL susceptibility in children of Brazilian Amazon population, which has a high degree of inter-ethnic admixture. Ancestry analysis was estimated using a panel of 48 autosomal ancestry informative markers. 130 B-cell ALL patients and 125 healthy controls were included in this study. The odds ratios and 95% confidence intervals were adjusted for confounders. The results indicated an association between the investigated INDEL polymorphisms in CASP8 (rs3834129), CYP19A1 (rs11575899) e XRCCI (rs3213239) genes in the development of B-cell ALL. The carriers of Insertion/Insertion (Ins/Ins) genotype of the polymorphism in CASP8 gene presented reduced chances of developing B-cell ALL (P=0.001; OR = 0.353; 95% CI = 0.192-0.651). The Deletion/Deletion (Del/Del) genotype of the polymorphism in CYP19A1 gene was associated to a lower chance of developing B-cell ALL (P=3.35 x 10(-6); OR = 0.121; 95% CI = 0.050-0.295), while Del/Del genotype of the polymorphism in XRCCI gene was associated to a higher chance of developing B-cell ALL (P=2.01 x 10(-4); OR = 6.559; 95% CI = 2.433-17.681). We also found that Amerindian ancestry correlates with the risk of B-cell ALL. For each increase of 10% in the Amerindian ancestry results in 1.4-fold chances of developing B-cell ALL (OR = 1.406; 95% IC = 1.123-1.761), while each increase of 10% in the European ancestry presents a protection effect in the development of B-cell ALL (OR = 0.666; 95% IC= 0.536-0.827). The results suggest that genetic factors influence leukemogenesis and might be explored in the stratification of B-cell ALL risk in admixed populations. (C) 2015 The Authors. Published by Elsevier Ltd.
机译：急性淋巴细胞白血病（ALL）是儿童常见的恶性肿瘤。使用与癌症发展途径相关的双等位基因插入/缺失（INDEL）型多态性研究癌症的遗传易感性可能有助于阐明ALL的病因。在这项研究中，我们调查了八个功能性INDEL多态性的作用以及遗传祖先对巴西亚马孙族人群中B细胞ALL易感性的影响，该族裔之间存在高度的混合。使用一组48个常染色体祖先信息性标记物评估祖先分析。本研究包括130名B细胞ALL患者和125名健康对照。针对混杂因素调整了优势比和95％置信区间。结果表明在B细胞ALL的发育中，在CASP8（rs3834129），CYP19A1（rs11575899）和XRCCI（rs3213239）基因中研究的INDEL多态性之间存在关联。 CASP8基因多态性的插入/插入（Ins / Ins）基因型携带者出现B细胞ALL的机会减少（P = 0.001; OR = 0.353; 95％CI = 0.192-0.651）。 CYP19A1基因多态性的缺失/删除​​（Del / Del）基因型与发生B细胞ALL的机会较低相关（P = 3.35 x 10（-6）; OR = 0.121; 95％CI = 0.050-0.295 ），而XRCCI基因多态性的Del / Del基因型与发展B细胞ALL的机会更高有关（P = 2.01 x 10（-4）; OR = 6.559; 95％CI = 2.433-17.681）。我们还发现，美洲印第安人血统与B细胞ALL的风险相关。在美洲血统中每增加10％，导致发展B细胞ALL的机会是1.4倍（OR = 1.406; 95％IC = 1.123-1.761），而在欧洲血统中每增加10％，则具有保护作用。在B细胞ALL的发展过程中（OR = 0.666; 95％IC = 0.536-0.827）。结果表明遗传因素影响白血病的发生，并可能在混合人群的B细胞ALL风险分层中进行探索。 （C）2015作者。由Elsevier Ltd.发布

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号