The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.

Rush EA; Schlesinger KW; Watkins SC; Redner RL

首页> 外文期刊>Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis >The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.

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The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.

机译：与APL的t（5; 17）变体相关的NPM-RAR融合蛋白不与PML相互作用。

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The PML protein localizes to regions of the nucleus known as nuclear bodies or PODs. However, in t(15;17) Acute Promyelocytic Leukemia (APL) blasts, PML is found in a micro-punctate pattern. In order to test the hypothesis that delocalization of PML from PODs is necessary for APL, we investigated the interaction of the t(5;17) APL fusion protein NPM-RAR with PML. NPM-RAR localizes diffusely throughout the nucleoplasm. NPM-RAR does not alter the localization of PML in transfected HeLa cells, and does not associate with PML in vitro. These studies suggest that NPM-RAR does not interact with PML.

机译：PML蛋白位于称为核小体或POD的核区域。但是，在t（15; 17）急性早幼粒细胞白血病（APL）母细胞中，PML以微点状模式被发现。为了检验APL必须从POD中PML脱位的假设，我们研究了t（5; 17）APL融合蛋白NPM-RAR与PML的相互作用。 NPM-RAR散布在整个核质中。 NPM-RAR不会改变转染的HeLa细胞中PML的定位，并且在体外不与PML相关。这些研究表明NPM-RAR不与PML相互作用。

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《Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis》 |2006年第8期|共8页
作者
Rush EA; Schlesinger KW; Watkins SC; Redner RL;
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正文语种 eng
中图分类肿瘤学;
关键词
Leukoencephalopathy; Progressive Multifocal; NPM; Receptors; Retinoic Acid; 脑白质病; 进行性多病灶; 受体; 维甲酸;

机译：Leukoencephalopathy;Progressive Multifocal;NPM;Receptors;Retinoic Acid;脑白质病;进行性多病灶;受体;维甲酸;

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1. The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML. [J] . Rush EA, Schlesinger KW, Watkins SC, Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2006,第8期

机译：与APL的t（5; 17）变体相关的NPM-RAR融合蛋白不与PML相互作用。
2. NPM-RAR, not the RAR-NPM reciprocal t(5;17)(q35;q21) acute promyelocytic leukemia fusion protein, inhibits myeloid differentiation [J] . PollockS.L., RushE.A., RednerR.L. Leukemia and lymphoma . 2014,第6期

机译：NPM-RAR，而不是RAR-NPM相互的t（5; 17）（q35; q21）急性早幼粒细胞白血病融合蛋白，可抑制骨髓分化
3. Extrinsic Apoptosis Is Impeded by Direct Binding of the APL Fusion Protein NPM-RAR to TRADD [J] . Chattopadhyay Anuja, Hood Brian L., Conrads Thomas P., Molecular cancer research: MCR . 2014,第9期

机译：外源性凋亡受到APL融合蛋白NPM-RAR与TRADD直接结合的阻碍
4. PCSK9 and Its Variants: An Unbiased Global Proteomic Study to Identify Interactors and Effects on Protein Trafficking [C] . Kiara Ge Chu, Zhibin Ning, Janice Mayne ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：PCSK9及其变体：一项无偏见的全球蛋白质组学研究，以识别互动者和对蛋白质贩运的影响
5. Mitochondrial dynamics, mechanisms and meaning: Investigations into fusion and fission proteins Mitofusin 2 and MAPL [D] . Neuspiel, Margaret 2008

机译：线粒体动力学，机制和意义：融合蛋白和裂变蛋白Mitofusin 2和MAPL的研究
6. Extrinsic Apoptosis is Impeded by Direct Binding of the APL Fusion Protein NPM-RAR to TRADD [O] . Anuja Chattopadhyay, Brian L. Hood, Thomas P. Conrads, -1

机译：外源性凋亡受APL融合蛋白NPM-RAR与TRADD直接结合的阻碍
7. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia [O] . Fuchs, Uta, Rehkamp, Gönna, Haas, Oskar A., 2001

机译：人类福明结合蛋白17（FBP17）与分选神经毒素SNX2相互作用，是急性髓性白血病中的MLL融合伴侣

The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.

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