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首页> 外文期刊>Cell motility and the cytoskeleton >Non-centrosomal microtubule-organising centres in cold-treated cultured Drosophila cells.
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Non-centrosomal microtubule-organising centres in cold-treated cultured Drosophila cells.

机译：冷处理培养的果蝇细胞中的非中心微管组织中心。

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摘要

In this paper we describe a new type of non-centrosomal microtubule-organising centre (MTOC), which is induced by cold treatment of certain cultured Drosophila cells and allows rapid reassembly of microtubule (MT) arrays. Prolonged cooling of two types of cultured Drosophila cells, muscle cells in primary culture and a wing imaginal disc cell line Cl.8+ results in disassembly of MT arrays and induces the formation of clusters of short MTs that have not been described before. Upon rewarming, the clusters are lost and the MT array is re-established within 1 h. In Cl.8+ cells, gamma-tubulin-containing centrosomes are detected, both in cell extensions and in the expected juxtanuclear position, and gamma-tubulin co-localises with the cold-induced MT clusters. The MT plus-end-binding protein, Drosophila EB1, decorates growing tips of MTs extending from clusters. We conclude that the cold-induced MT clusters represent acentrosomal MTOCs, allowing rapid reassembly of MT arrays following exposure to cold.
机译：在本文中，我们描述了一种新型的非中心体微管组织中心（MTOC），它是通过对某些培养的果蝇细胞进行冷处理而诱导的，并允许快速重组微管（MT）阵列。两种类型的果蝇细胞，初级培养中的肌肉细胞和翼状假想盘状细胞系Cl.8 +的长时间冷却会导致MT阵列的解体并诱导形成以前未描述的短MT簇。重新加热后，群集将丢失，并且MT阵列将在1小时内重新建立。在Cl.8 +细胞中，在细胞延伸和预期的近核位置均检测到含γ-微管蛋白的中心体，并且γ-微管蛋白与冷诱导的MT簇共定位。 MT加端结合蛋白Drosophila EB1装饰了从簇延伸而来的MT的生长尖端。我们得出的结论是，冷诱导的MT簇代表着无体MTOC，使MT阵列在暴露于寒冷后能快速重新组装。

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