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Cytokine Profile in Children with Inflammatory Bowel Disease

机译：炎性肠病患儿的细胞因子谱

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Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) characterized by immune reactivity against microbial and auto-antigens. This work was designed to study the cytokine profile in blood serum and coproextracts of children with CD and UC. The studied patients consisted of 17 children with CD (group I), 17 children with UC (group II), and 18 controls with intestinal dysbiosis (group III). The diagnosis of UC and CD was based on accepted clinical and endoscopic criteria. The levels of 13 cytokines (IL-1 beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-17A, TNF-alpha, TGF-beta, and IFN-gamma) were determined in blood sera and coproextracts of the patients and controls using the BioPlex technology. The level of IL-17A was significantly increased and that of TGF-beta was significantly decreased in the blood serum of the patients with IBDs. Changes in the cytokine profile in the coproextracts affected the wider spec trum of cytokines. The levels of proinflammatory cytokines (IL-2, IL-4, IL-6, IL-12p70, TNF-alpha, and IFN-gamma) were increased 6-9-fold, whereas the level of the anti-inflammatory cytokine IL-10 was increased 3-fold. The cytokine balance was shifted to the proinflammatory cytokines. The TGF-beta level was increased 9-fold and that of IL-17A was increased 3 fold. Thus, the cytokine profile in the coproextracts was more informative than that of the blood serum. The determination of cytokines in coproextracts is simple and noninvasive.
机译：克罗恩氏病（CD）和溃疡性结肠炎（UC）是炎症性肠病（IBD），其特征在于针对微生物和自身抗原的免疫反应性。这项工作旨在研究CD和UC儿童血清和共提取物中的细胞因子谱。研究的患者包括17例CD儿童（I组），17例UC儿童（II组）和18例肠道营养不良的对照组（III组）。 UC和CD的诊断基于公认的临床和内窥镜检查标准。 13种细胞因子（IL-1 beta，IL-2，IL-4，IL-5，IL-6，IL-7，IL-8，IL-10，IL-12p70，IL-17A，TNF-alpha的水平，TGF-β和IFN-γ）是使用BioPlex技术在患者和对照的血清中以及共提取物中测定的。 IBD患者的血清中IL-17A水平显着升高，TGF-β水平显着降低。共提取物中细胞因子谱的变化影响了更广泛的细胞因子谱。促炎细胞因子（IL-2，IL-4，IL-6，IL-12p70，TNF-α和IFN-γ）的水平提高了6-9倍，而抗炎细胞因子IL- 10增加了3倍。细胞因子平衡转移到促炎细胞因子。 TGF-β水平增加了9倍，IL-17A水平增加了3倍。因此，共提取物中的细胞因子概况比血清中的更为丰富。共提取物中细胞因子的测定是简单且无创的。

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