Higher incidence of viable Mycobacterium leprae within the nerve as compared to skin among multibacillary leprosy patients released from multidrug therapy.

Shetty VP; Suchitra K; Uplekar MW; Antia NH

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Higher incidence of viable Mycobacterium leprae within the nerve as compared to skin among multibacillary leprosy patients released from multidrug therapy.

机译：从多药治疗中释放出来的多细菌性麻风患者中，与皮肤相比，神经内活的分枝杆菌麻风的发病率更高。

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As identified by a significant growth in the footpads of immunosuppressed mice, the incidence of viable bacteria in a group of 26 multibacillary (BL-LL) patients released from multidrug (MDT) treatment was found to be two times more in the nerves (46%) as compared to skin (23%). Evidently there was a positive correlation between the overall bacterial load and the incidence of viable organisms. Bacterial growth was also observed in two out of five cases where neither the skin nor the nerve homogenate had shown any presence of acid-fast bacilli. Histopathology of biopsies, skin as well as nerve, including those having viable bacteria did not show any features of active disease.

机译：如通过免疫抑制小鼠的脚垫显着生长所确定的，发现在26名通过多药（MDT）治疗释放的多细菌（BL-LL）患者中，活细菌的发生率是神经的两倍（46％），而不是皮肤（23％）。显然，总细菌载量与活生物体的发生率之间呈正相关。在五分之二的病例中也观察到细菌生长，其中皮肤和神经匀浆均未显示出抗酸杆菌的存在。活检，皮肤和神经的组织病理学，包括那些有活菌的组织病理学，均未显示出活动性疾病的任何特征。

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来源
《Leprosy review》 |1997年第2期|共8页
作者
Shetty VP; Suchitra K; Uplekar MW; Antia NH;
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原文格式 PDF
正文语种 eng
中图分类皮肤病学与性病学;传染病;
关键词
Leprostatic Agents; Leprosy; Mycobacterium leprae; Peripheral Nerves; Skin; 麻风抑制药; 麻风; 分支杆菌; 麻风; 周围神经; 皮肤;

机译：Leprostatic Agents;Leprosy;Mycobacterium leprae;Peripheral Nerves;Skin;麻风抑制药;麻风;分支杆菌;麻风;周围神经;皮肤;

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1. Higher incidence of viable Mycobacterium leprae within the nerve as compared to skin among multibacillary leprosy patients released from multidrug therapy. [J] . Shetty VP, Suchitra K, Uplekar MW, Leprosy review . 1997,第2期

机译：从多药治疗中释放出来的多细菌性麻风患者中，与皮肤相比，神经内活的分枝杆菌麻风的发病率更高。
2. Incidence of ocular morbidity among multibacillary leprosy patients during a 2 year course of multidrug therapy. [J] . Daniel E, Ffytche TJ, Sundar Rao PS, British journal of ophthalmology . 2006,第5期

机译：在多药治疗的2年疗程中，多杆菌性麻风患者的眼病发病率。
3. Incidence of ocular complications in patients with multibacillary leprosy after completion of a 2 year course of multidrug therapy. [J] . Daniel E, Ffytche TJ, Kempen JH, British journal of ophthalmology . 2006,第8期

机译：完成2年疗程的多药麻风病患者的眼部并发症发生率。
4. A novel approach to enumerate and compare Mycobacterium leprae in the endoneurium versus the epineurium of the posterior tibial nerves of infected nine-banded armadillos using laser pressure catapulting and PCR [D] . Emery, Corinthia. 2013

机译：一种使用激光压力弹射和PCR枚举和比较感染的九带犰狳的胫骨后神经的神经内膜与皮层中分枝杆菌的麻风分枝杆菌的新方法
5. Mycobacterium leprae-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT [O] . Emerith M. Hungria, Samira Bührer-Sékula, Regiane M. Oliveira, -1

机译：常规12剂量多药疗法（MDT）或均匀6剂量MDT治疗期间和治疗后多发麻风病患者的分枝杆菌麻风病特异性抗体减少
6. The allocation of leprosy patients into paucibacillary and multibacillary groups for multidrug therapy, taking into account the number of body areas affected by skin, or skin and nerve lesions [O] . W. H. VAN BRAKEL, R. DE SOLDENHOFF, A. C. McDOUGALL 1992

机译：麻风病患者将麻风病患者分配到白拍治疗中，考虑到受皮肤影响的身体区域的数量，或皮肤和神经病变

Higher incidence of viable Mycobacterium leprae within the nerve as compared to skin among multibacillary leprosy patients released from multidrug therapy.

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