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首页> 外文期刊>Biochemistry >Plasticity of Tumor Cell Migration: Acquisition of New Properties or Return to the Past?
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Plasticity of Tumor Cell Migration: Acquisition of New Properties or Return to the Past?

机译：肿瘤细胞迁移的可塑性：获得新特性还是回到过去？

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During tumor development cancer cells pass through several stages when cell morphology and migration abilities change remarkably. These stages are named epithelial—mesenchymal and mesenchymal—amoeboid transitions. The molecular mechanisms underlying cell motility are changing during these transitions. As result of transitions the cells acquire new characteristics and modes of motility. Cell migration becomes more independent from the environmental conditions, and thus cell dissemination becomes more aggressive, which leads to formation of distant metastases. In this review we discuss the characteristics of each of the transitions, cell morphology, and the specificity of cellular structures responsible for different modes of cell motility as well as molecular mechanisms regulating each transition.
机译：在肿瘤发生期间，癌细胞会经历几个阶段，此时细胞的形态和迁移能力会发生显着变化。这些阶段称为上皮－间充质和间充质－类阿米巴过渡。在这些过渡过程中，细胞运动的分子机制正在发生变化。作为过渡的结果，细胞获得了新的运动特征和模式。细胞迁移变得更不受环境条件的影响，因此细胞传播变得更加积极，这导致形成远处转移。在这篇综述中，我们讨论了每种过渡的特征，细胞形态以及负责不同细胞运动模式的细胞结构的特异性以及调节每种过渡的分子机制。

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