• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cardiovascular therapeutics >Statins--is there potential for uncovering new benefits (or detriments)?
【24h】

Statins--is there potential for uncovering new benefits (or detriments)?

机译：他汀类药物-是否有潜力发现新的利益（或危害）？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Despite over 20 years of clinical use and 15 years of clinical trial data, we still do not have a complete understanding of the mechanisms of action or full utility of statins as a class of drugs. The possibility of their use as a treatment for prevention of peri-operative morbidity and mortality is one of the newest indications being explored for this class of drugs. Issues regarding drug dosing and timing may rely on being able to elucidate and separate potential pleiotropic actions from lipid-lowering actions to identify the optimal benefit of these drugs in the peri-operative setting. Careful consideration of these two actions need to be considered in the design of adequately powered clinical trials to test the potential utility and safety of using statins in the peri-operative setting.
机译：尽管有20多年的临床使用和15年的临床试验数据，但我们仍然对他汀类药物的作用机理或完全效用尚不完全了解。将其用作预防围手术期发病率和死亡率的治疗方法的可能性是此类药物正在探索的最新适应症之一。有关药物剂量和时机的问题可能取决于能够阐明和将潜在的多效性作用与降脂作用区分开来，以识别围手术期这些药物的最佳益处。在设计足够动力的临床试验以测试围手术期使用他汀类药物的潜在效用和安全性时，必须仔细考虑这两种作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号