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首页> 外文期刊>Cardiovascular therapeutics >Safety of herbal supplements: a guide for cardiologists.
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Safety of herbal supplements: a guide for cardiologists.

机译：草药补品的安全性：心脏病专家指南。

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摘要

Many patients use herbal supplements to treat chronic cardiovascular conditions and often combine herbal ingredients with cardiovascular medications. However, physicians do not reliably elicit a history of herbal use from their patients and may overlook herbal supplements' adverse effects. Although often considered harmless by patients, herbal supplements may cause adverse cardiovascular effects from an herbal ingredient, a contaminant, or an herb-drug interaction. Herbal stimulants, including bitter orange, ephedra, caffeine, guarana, mate, kola, areca, lobelia, khat, and others are the most common category of herbal therapies to cause cardiovascular effects. However, dozens of other herbal ingredients have also been linked to adverse cardiovascular events. In addition to listed ingredients, herbal supplements may become contaminated at a number of stages during production. Pesticides, heavy metals, bacteria, and pharmaceutical agents have been detected in herbal supplements. Supposedly "herbal" products that are adulterated with prescription anorectics, antidepressants, diuretics, phosphodiesterase-5 inhibitors along with other medications have been identified throughout Europe, North America, and Asia. All of these adulterants have potential cardiovascular effects. Herbal interactions with a variety of cardiovascular medications may also lead to adverse events. Herbal ingredients may cause pharmacokinetic as well as pharmacodynamic herb-drug interactions. We review clinically relevant patterns of adverse cardiovascular reactions to herbal supplements, and we provide resources and recommendations for practicing cardiologists evaluating patients with suspected herbal adverse effects.
机译：许多患者使用草药补品来治疗慢性心血管疾病，并经常将草药成分与心血管药物结合使用。但是，医生不能可靠地从患者身上得出草药使用史，并且可能忽略了草药补品的不良作用。尽管患者通常认为无害，但草药补充剂可能会由于草药成分，污染物或草药与药物的相互作用而引起不良的心血管影响。包括苦橙，麻黄，咖啡因，瓜拉纳，伴侣，可乐，槟榔，山梗菜，卡塔叶等在内的草药兴奋剂是引起心血管效应的最常见草药疗法类别。但是，许多其他草药成分也与不良心血管事件有关。除所列成分外，草药补品在生产过程中的许多阶段都可能受到污染。在草药补品中已检测到农药，重金属，细菌和药剂。据称，在整个欧洲，北美和亚洲都发现了掺有处方厌食药，抗抑郁药，利尿药，磷酸二酯酶-5抑制剂以及其他药物的“草药”产品。所有这些掺杂物都有潜在的心血管作用。草药与多种心血管药物的相互作用也可能导致不良事件。草药成分可能会引起药代动力学以及药效相互作用。我们回顾了对草药补充剂的不良心血管反应的临床相关模式，并且我们为实践心内科医生提供了资源和建议，以评估可疑草药副作用的患者。

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