Primary central nervous system lymphoma: the challenge continues.

Wirth A

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Primary central nervous system lymphoma: the challenge continues.

机译：原发性中枢神经系统淋巴瘤：挑战仍在继续。

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Clinicians managing primary central nervous system lym-phoma (PCNSL) face challenges in two distinct areas. The first is the disease itself. PCNSL is an aggressive malignancy for which current therapies have limited long-term success, and for which treatment intensification can often lead to unacceptable toxicity. The second challenge is the knowledge base informing the management of this condition, which rests largely on phase II trials and retrospective studies, with a paucity of prospective randomized trial data. Thus, key questions regarding optimal management remain unresolved.

机译：管理原发性中枢神经系统淋巴瘤（PCNSL）的临床医生在两个不同领域面临挑战。首先是疾病本身。 PCNSL是一种侵袭性恶性肿瘤，当前的治疗方法长期无法获得成功，其强化治疗常常会导致不可接受的毒性。第二个挑战是告知管理该病的知识库，该知识库主要取决于II期试验和回顾性研究，缺乏前瞻性随机试验数据。因此，关于最佳管理的关键问题仍未解决。

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《Leukemia and lymphoma》 |2011年第11期|共2页
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Wirth A;
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正文语种 eng
中图分类肿瘤学;
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1. Primary central nervous system lymphoma: the challenge continues. [J] . Wirth A Leukemia and lymphoma . 2011,第11期

机译：原发性中枢神经系统淋巴瘤：挑战仍在继续。
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3. Primary central nervous system post-transplantation lymphoproliferative disorder: an International Primary Central Nervous System Lymphoma Collaborative Group Report. [J] . Cavaliere R, Petroni G, Lopes M Cancer: A Journal of the American Cancer Society . 2010,第4期

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4. Mutational profile of Diffuse Large B-cell Lymphoma with central nervous system relapse: analysis of CBioPortal for Cancer Genomics database [C] . Elena Voropaeva, Olga Beresina, Tatyana Pospelova, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

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5. Utility of apparent diffusion coefficients in the evaluation of primary central nervous system lymphoma. [D] . Gilbert, John Webster. 2012

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6. Central nervous system recurrence of systemic lymphoma in the era of stem cell transplantation – an International Primary Central Nervous System Lymphoma Study Group project [O] . Jacoline E. Bromberg, Jeanette K. Doorduijn, Gerald Illerhaus, 2013

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Primary central nervous system lymphoma: the challenge continues.

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