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首页> 外文期刊>Landbauforschung Volkenrode: Wissenschaftliche Mitteilungen der Bundesforschungsanstalt fur Landwirtschaft Braunschweig-Volkenrode (FAL) >Domestic cultivation of the medicinal plant Tanacetum parthenium for the development of a drug for migraine prevention. Collection and evaluation of genetic resources of the medicinal plant Tanacetum parthenium (L.) Schultz Bip.
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Domestic cultivation of the medicinal plant Tanacetum parthenium for the development of a drug for migraine prevention. Collection and evaluation of genetic resources of the medicinal plant Tanacetum parthenium (L.) Schultz Bip.

机译：在国内种植药用单性艾菊，以开发预防偏头痛的药物。药用植物艾菊（L.）Schultz Bip的遗传资源的收集和评估。

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Sesquiterpene lactones with parthenolide as the main representative prevalent in flowers and leaves of the medicinal plant feverfew (Tanacetum parthenium) provide a basis for developing a drug for the prophylactic treatment of migraine. To test if it is possible to guarantee a homogenous supply of the plant raw material for industrial processing, we evaluated 45 worldwide available accessions for vitality, crop productivity, optimum harvest time and parthenolide content. Biomass yield varied significantly between the different feverfew accessions and was primarily depending on the harvest time. Single plant yield increased by delaying the first cut to the end of the flowering period compared to the first cut before flowering in the first growing season. Maximum biomass yield reached 70 g dry matter per plant when plants were harvested at the end of the flowering period. Accessions with parthenolide contents below 3 mg/g DM were excluded from further experiments because the parthenolide content was too low for an efficient extraction and thus, the material was not suitable for drug production. However, several accessions produced parthenolide contents above the threshold as well as high biomass yield. Parthenolide content varied from >3 up to 20.5 mg/g DM, and single plant dry matter yield ranged from >15 to 70 g per plant. In the first year, we recommend one harvest at the end of the flowering period. In the second growing season two cuts at full blossom would provide sufficient parthenolide and biomass yield..
机译：以小白菊内酯为主要代表的倍半萜内酯在药用植物小白菊（艾菊（Tanacetum parthenium））的花和叶中普遍存在，为开发预防偏头痛的药物奠定了基础。为了测试是否有可能保证为工业加工提供均匀的植物原料供应，我们评估了全球45种有效成分的生命力，作物生产力，最佳收获时间和小白菊内酯含量。不同的小白菊品种之间的生物量产量差异很大，并且主要取决于收获时间。与在第一个生长季节开花前的初切相比，通过将初切推迟到开花期结束来提高单株产量。开花期结束时收获植物时，每株植物的最大生物量产量达到70 g干物质。单性酚含量低于3 mg / g DM的保藏物被排除在进一步的实验之外，因为单性酚含量太低而无法有效提取，因此该材料不适合用于药物生产。然而，一些种质产生的单酚含量高于阈值，并且生物量高。爬山虎的含量从> 3到20.5 mg / g DM不等，单株植物干物质产量在每株植物> 15至70 g的范围内。在第一年，我们建议在开花期结束时收获一次。在第二个生长季节，两次切花盛开时将提供足够的小白菊内酯和生物量产量。

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