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首页> 外文期刊>Cardiovascular therapeutics >Targeting inflammation as a therapeutic strategy in accelerated atherosclerosis in rheumatoid arthritis.
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Targeting inflammation as a therapeutic strategy in accelerated atherosclerosis in rheumatoid arthritis.

机译：将炎症作为类风湿关节炎加速动脉粥样硬化的治疗策略。

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Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 1% of the population. Patients have reduced life expectancy and the leading cause of death is cardiovascular disease (CVD), with patients experiencing at least a 2-fold increased risk of myocardial infarction. RA is recognized as an independent risk factor for CVD. Inflammation is a key contributor to the pathogenesis of atherosclerosis and cardiovascular events. As a common catalyst of both diseases, inflammation is the likely cause of increased prevalence of CVD in the RA population. Abating disease-related inflammation in RA may be an effective strategy in reducing CVD risk. Several other therapies used to modify cardiovascular risk factors in the general population such as statins and angiotensin-converting enzyme inhibitors are under investigation in patients with RA. This review discusses the parallels in the pathology of RA and atherosclerosis and discusses current therapies for RA and how they affect cardiovascular risk.
机译：类风湿关节炎（RA）是一种自身免疫性疾病，影响大约1％的人口。患者的预期寿命缩短，并且死亡的主要原因是心血管疾病（CVD），患者的心肌梗塞风险至少增加了2倍。 RA被认为是CVD的独立危险因素。炎症是导致动脉粥样硬化和心血管事件的关键因素。作为这两种疾病的常见催化剂，炎症可能是RA人群中CVD患病率增加的原因。减轻RA中与疾病相关的炎症可能是降低CVD风险的有效策略。 RA患者正在研究其他几种用于改变普通人群中心血管危险因素的疗法，例如他汀类药物和血管紧张素转化酶抑制剂。这篇综述讨论了RA和动脉粥样硬化的病理学相似之处，并讨论了RA的当前疗法及其对心血管风险的影响。

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