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首页> 外文期刊>Cardiovascular therapeutics >Serum Levels of Advanced Glycation End Products (AGEs) are Inversely Associated with the Number and Migratory Activity of Circulating Endothelial Progenitor Cells in Apparently Healthy Subjects
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Serum Levels of Advanced Glycation End Products (AGEs) are Inversely Associated with the Number and Migratory Activity of Circulating Endothelial Progenitor Cells in Apparently Healthy Subjects

机译：晚期糖化终产物（AGEs）的血清水平与显然健康的受试者中循环内皮祖细胞的数量和迁移活性成反比。

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Objectives: Endothelial progenitor cells (EPCs) have been shown to participate in the process of vascular repair, thus playing a protective role against cardiovascular disease (CVD). It is known that atherosclerotic risk factors could affect EPC number and function. Advanced glycation end products (AGEs) contribute to the pathogenesis of atherosclerosis as well. However, as far as we know, there is no report to show the relationship between serum AGE levels and circulating EPCs in humans. Therefore, in this study, we investigated whether serum level of AGEs was associated with EPC number and functions in apparently healthy subjects, independent of traditional cardiovascular risk factors. Research Design and Methods: Apparently healthy volunteers (34.6 ± 6.9 years old, 40 males and 8 females) who were not on any medications underwent a complete history and physical examination, determination of blood chemistries, including AGEs, and number, differentiation and migratory activity of circulating EPCs. Results: Serum AGEs levels were 9.20 ± 1.85 U/mL. Multiple stepwise regression analysis revealed that serum levels of AGEs and smoking were independently correlated with reduced number of EPCs. Further, female, AGEs, and reduced HDL-cholesterol levels were independently associated with impaired migratory activity of circulating EPCs. Conclusions: This study demonstrated for the first time that the serum level of AGEs was one of the independent correlates of decreased cell number and impaired migratory activity of circulating EPCs in apparently healthy subjects. Our present observations suggest that even in young healthy subjects, serum level of AGEs may be a biomarker that could predict the progression of atherosclerosis and future cardiovascular events.
机译：目的：内皮祖细胞（EPC）已被证明参与血管修复过程，从而对心血管疾病（CVD）起保护作用。众所周知，动脉粥样硬化的危险因素可能会影响EPC的数量和功能。晚期糖基化终末产物（AGEs）也有助于动脉粥样硬化的发病。但是，据我们所知，尚无报道显示血清AGE水平与人体内循环EPC之间的关系。因此，在这项研究中，我们调查了在显然健康的受试者中，血清AGEs的水平是否与EPC数量和功能相关，而与传统的心血管危险因素无关。研究设计和方法：显然健康的志愿者（34.6±6.9岁，40例男性，8例女性）没有使用任何药物，都经过了完整的病史和体格检查，血液化学成分（包括AGEs）的测定，数量，分化和迁移活动循环EPC。结果：血清AGEs水平为9.20±1.85U / mL。多元逐步回归分析显示，血清AGEs和吸烟水平与EPC数量减少独立相关。此外，女性，AGEs和降低的HDL-胆固醇水平与循环EPC的迁移活动受损独立相关。结论：这项研究首次证明了血清AGEs水平是明显健康受试者中循环EPCs数量减少和循环EPC迁移活动受损的独立相关因素之一。我们目前的观察结果表明，即使在年轻健康的受试者中，AGEs的血清水平也可能是可预测动脉粥样硬化进展和未来心血管事件的生物标志物。

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