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Novel Effects of Macrolide Antibiotics on Cardiovascular Diseases

机译：大环内酯类抗生素对心血管疾病的新作用

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摘要

Macrolide antibiotics are broadly used for the treatment of various microbial infections. However, they are also known to have multiple biologic effects, such as alteration of inflammatory factors and matrix metalloproteinases (MMPs). Because of controversial results in clinical trials, the effects of macrolides on cardiovascular diseases are still to be elucidated. It has been reported that MMP activity is upregulated in various cardiovascular diseases, such as myocarditis, cardiac transplant rejection and myocardial infarction. However, little is known about the effects of macrolides on cardiovascular diseases. We have reported that clarithromycin suppressed the development of myocarditis, cardiac rejection and myocardial ischemia using animal models. In this article, we reviewed the roles of MMPs in cardiovascular diseases and the effects of macrolides on the prevention of adverse tissue remodeling.
机译：大环内酯类抗生素被广泛用于治疗各种微生物感染。但是，还已知它们具有多种生物学作用，例如炎症因子和基质金属蛋白酶（MMP）的改变。由于临床试验中有争议的结果，大环内酯类药物对心血管疾病的影响尚待阐明。据报道，在多种心血管疾病，例如心肌炎，心脏移植排斥反应和心肌梗塞中，MMP活性被上调。然而，关于大环内酯类药物对心血管疾病的影响知之甚少。我们已经报道了克拉霉素使用动物模型抑制了心肌炎，心脏排斥反应和心肌缺血的发展。在本文中，我们综述了MMP在心血管疾病中的作用以及大环内酯类药物在预防不良组织重塑中的作用。

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