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Effect of FGF-1 and FGF-2 on VEGF binding to human umbilical vein endothelial cells.

机译:FGF-1和FGF-2对VEGF与人脐静脉内皮细胞结合的影响。

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摘要

When FGF-1 or FGF-2 and VEGF were added together, the mitogenic effect of FGF-1 or FGF-2 and VEGF on HUVEC was additive. However, when HUVECs were preincubated for 2 days with 10 ng/ml FGF-1 in the absence of VEGF, the Scatchard plot of [125I]VEGF binding sites was shifted to the right: both affinity classes of VEGF binding sites were equally affected, such that the total number of sites increased twofold. It is suggested that this type of interaction may be related to tumor angiogenesis and wound repair. Copyright 2001 Academic Press.
机译:当FGF-1或FGF-2和VEGF一起添加时,FGF-1或FGF-2和VEGF对HUVEC的促有丝分裂作用是加和的。但是,当在不存在VEGF的情况下将HUVEC与10 ng / ml FGF-1预孵育2天时,[125I] VEGF结合位点的Scatchard图向右偏移:两种VEGF结合位点的亲和力类别均受到相同的影响,这样网站的总数增加了两倍。提示这种相互作用可能与肿瘤血管生成和伤口修复有关。版权所有2001学术出版社。

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