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首页> 外文期刊>Cell biology international. >Laminin-2/4 from human placenta is a better adhesion agent for primary keratinocytes than laminin-1 from EHS sarcoma.
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Laminin-2/4 from human placenta is a better adhesion agent for primary keratinocytes than laminin-1 from EHS sarcoma.

机译：与来自EHS肉瘤的laminin-1相比，来自人胎盘的Laminin-2 / 4对原代角质形成细胞具有更好的粘附性。

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摘要

A comparison of the adhesion of human primary keratinocytes to laminin-1 from murine EHS sarcoma and laminin-2/4 from human placenta was carried out using two methods, cell adhesion to substrates covered with the laminin isoforms, and interaction of keratinocytes from suspension with latex beads coated with the proteins. Laminin-2/4 was considerably more potent as a promoter of attachment of primary human keratinocytes than laminin-1 (and fibronectin), with increased attachment of cells correlating well with the number of latex bead binding sites. Only small cells of diameter of less than 20 microm bound more than 5 beads. Staining of keratinocytes with involucrin antibodies confirmed the existence of an inverse relationship between laminin-2/4-coated bead binding and differentiation.
机译：使用两种方法比较人原代角质形成细胞与鼠EHS肉瘤中laminin-1的黏附以及人胎盘中laminin-2 / 4的黏附，细胞对层粘连蛋白同工型覆盖的基质的黏附以及悬浮液与角质形成素之间的相互作用用蛋白质包被的乳胶珠。层粘连蛋白2/4作为主要的人角质形成细胞附着的促进剂比层粘连蛋白1（和纤连蛋白）更有效，细胞附着增加与乳胶珠结合位点数量相关。只有直径小于20微米的小细胞结合了5个以上的珠子。用involucrin抗体染色角质形成细胞证实层粘连蛋白-2/4包被的珠结合与分化之间存在反比关系。

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