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首页> 外文期刊>Cell biology international. >Characterization of myogenic cell membrane: spontaneous formation of heterokaryotic myotubes between two different kinds of myoblasts.
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Characterization of myogenic cell membrane: spontaneous formation of heterokaryotic myotubes between two different kinds of myoblasts.

机译：成肌细胞膜的特征：两种不同类型的成肌细胞之间自发形成异核肌肌管。

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In a previous study, it has been shown that presumptive mouse C2 myoblast cells are strongly resistant to HVJ (hemaglutinating virus of Japan, Sendai virus)-mediated cell fusion, but do become capable of fusion upon differentiation. Quail myoblasts transformed with a temperature-sensitive mutant of Rous sarcoma virus (QM-RSV cells) also become more sensitive to HVJ-mediated cell fusion during differentiation. Investigations were undertaken to see whether heterokaryotic myotubes were formed spontaneously by co-culture of two different kinds of myogenic cells, QM-RSV cells and C2 cells. When both cells were committed to myotube formation, they spontaneously fused without HVJ on co-culture. On the other hand, when both or one of the cells were in the presumptive state, heterokaryons were not formed by co-culturing. Furthermore, committed QM-RSV cells did not fuse with non-myogenic cells. These results indicate that the membranes of myogenic cells change to become capable of fusion for myotube formation during differentiation. Copyright 2001 Academic Press.
机译：在先前的研究中，已经证明推定的小鼠C2成肌细胞对HVJ（日本的血凝病毒，仙台病毒）介导的细胞融合具有强抗性，但是在分化时确实能够融合。用劳氏肉瘤病毒（QM-RSV细胞）对温度敏感的突变体转化的鹌鹑成肌细胞在分化过程中对HVJ介导的细胞融合也变得更加敏感。进行研究以查看是否通过两种不同类型的成肌细胞，即QM-RSV细胞和C2细胞的共培养自发形成异核肌肌管。当两个细胞均参与肌管形成时，它们在共培养时自发融合而无HVJ。另一方面，当两个或两个细胞都处于推测状态时，通过共同培养不会形成异核体。此外，定型的QM-RSV细胞不会与非肌原性细胞融合。这些结果表明，在分化过程中，成肌细胞的膜改变为能够融合以形成肌管。版权所有2001，学术出版社。

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