Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells.

Chen JH; Wang XC; Sato JD

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Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells.

机译：肝素结合蛋白HBp17对细胞DNA合成的双功能作用。

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A 17 kD heparin-binding protein (HBp17) has a biphasic dose-dependent effect on DNA synthesis in 3T3 cells. Maximal stimulation of DNA synthesis occurs at 8 ng/ml HBp17, but a half-maximal inhibition occurs at approximately 500 ng/ml. This inhibition can easily be reversed by addition of 400 pg/ml aFGF or 100 pg/ml bFGF, whereas EGF had no effect. This biphasic action of HBp17 was also seen in human umbilical vein endothelial cells (HUVEC), whereas it was not found in the malignant cell line, A431-AJC. The functional relationship between HBp17 and FGF is discussed. Copyright 2001 Academic Press.

机译：17 kD肝素结合蛋白（HBp17）对3T3细胞中的DNA合成具有双相剂量依赖性。 DNA合成的最大刺激发生在8 ng / ml HBp17处，而半最大抑制发生在大约500 ng / ml处。加入400 pg / ml aFGF或100 pg / ml bFGF可以很容易地逆转这种抑制作用，而EGF没有作用。 HBp17的这种双相作用也见于人脐静脉内皮细胞（HUVEC），而在恶性细胞系A431-AJC中未发现。讨论了HBp17和FGF之间的功能关系。版权所有2001学术出版社。

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《Cell biology international.》 |2001年第6期|共4页
作者
Chen JH; Wang XC; Sato JD;
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正文语种 eng
中图分类细胞生物学;
关键词
Carrier Proteins; DNA Replication; Fibroblast Growth Factor; Basic; Fibroblast Growth Factor; Acidic; 载体蛋白质类; DNA复制;

机译：Carrier Proteins;DNA Replication;Fibroblast Growth Factor;Basic;Fibroblast Growth Factor;Acidic;载体蛋白质类;DNA复制;

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机译：肝素结合蛋白HBp17对细胞DNA合成的双功能作用。
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Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells.

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