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首页> 外文期刊>Cell biology international. >BCL-2 does not control programmed cell death in the IPLB-LdFB cell line from the insect Lymantria dispar.
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BCL-2 does not control programmed cell death in the IPLB-LdFB cell line from the insect Lymantria dispar.

机译：BCL-2不能控制来自昆虫黄单胞菌的IPLB-LdFB细胞系中的程序性细胞死亡。

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摘要

In the insect Lymantria dispar cell line IPLB-LdFB the presence of a Bcl-2-like molecule has been demonstrated. The Western blot analysis performed on the cells incubated with 2-deoxy-D-ribose (dRib), an apoptotic inducer, revealed that, in comparison with the control, the Bcl-2 expression was unaffected. Furthermore, incubation of the insect cells with an anti-Bcl-2 polyclonal antibody inhibited the apoptotic effect induced by dRib, and provoked mitochondrial membrane depolarization without any apoptotic phenomena. Similar behaviour was observed using the K+ ionophore valinomycin. From these findings, we hypothesize that the L. dispar Bcl-2-like protein is essential for maintenance of the mitochondrial membrane potential, but not, as usually thought, for the regulation of programmed cell death.
机译：在昆虫狼尾草细胞系IPLB-LdFB中，已证实存在Bcl-2-样分子。对与凋亡诱导剂2-脱氧-D-核糖（dRib）孵育的细胞进行的蛋白质印迹分析表明，与对照相比，Bcl-2表达未受影响。此外，将昆虫细胞与抗Bcl-2多克隆抗体一起孵育可抑制dRib诱导的凋亡作用，并引起线粒体膜去极化而无任何凋亡现象。使用K +离子载体缬氨霉素观察到类似的行为。根据这些发现，我们推测L. dispar Bcl-2-like蛋白对于维持线粒体膜电位至关重要，但对于通常的程序性细胞死亡调节并非如此。

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