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首页> 外文期刊>Cell biology international. >CONNEXIN43 GAP JUNCTION LEVELS DURING DEVELOPMENT OF THE THORACIC AORTA ARE TEMPORALLY CORRELATED WITH ELASTIC LAMINAE DEPOSITION AND INCREASED BLOOD PRESSURE
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CONNEXIN43 GAP JUNCTION LEVELS DURING DEVELOPMENT OF THE THORACIC AORTA ARE TEMPORALLY CORRELATED WITH ELASTIC LAMINAE DEPOSITION AND INCREASED BLOOD PRESSURE

机译：胸主动脉发育过程中CONNEXIN43的间隙连接水平与弹性层沉积和血液压力升高暂时相关

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摘要

A characteristic property of the vascular smooth muscle cell is its ability to modulate between a contractile phenotype, responsible for control of vascular tone and tension, through to a synthetic phenotype, capable of migration and synthesis of extracellular matrix molecules. Smooth muscle cells are coupled by gap junctions, the membrane structures which permit direct intercellular passage of ions and small molecules, and which play a role both in electrical coupling and intercellular communication during patterning and development. We have previously found that connexin43 type gap junction expression is upregulated in the synthetic phenotype smooth muscle cell in vitro and during atherosclerotic plaque formation in human coronary arteries. On the basis of immunohistochemical labelling, confocal laser scanning microscopy and digital image analysis, we now report that relatively high levels of connexin43 are expressed during development of the rat thoracic aorta, temporally correlating with reported periods of smooth muscle cell proliferation and secretion of elastic laminae. A major peak in expression occurs at seven days post-natal, with a second less pronounced peak at 72 days post-natal. The principal peak in gap junction levels appears to coincide with increased post-natal blood pressure and aorta media thickening. The amount of gap junction labelling falls off to normal adult levels as the smooth muscle cells modulate towards the contractile phenotype and growth is completed. The results indicate an association between direct cell-to-cell communication and synthetic phenotype smooth muscle cell activity during aortic growth and patterning. (C) 1997 Academic Press Limited. [References: 48]
机译：血管平滑肌细胞的特征是其在负责控制血管紧张度和张力的收缩表型到合成表型之间调节的能力，该表型能够迁移和合成细胞外基质分子。平滑肌细胞通过间隙连接而耦合，该间隙连接允许离子和小分子直接在细胞间通过，并且在构图和显影过程中在电耦合和细胞间通讯中均发挥作用。我们以前已经发现，connexin43型间隙连接表达在体外和人冠状动脉粥样硬化斑块形成过程中在合成表型平滑肌细胞中上调。基于免疫组织化学标记，共聚焦激光扫描显微镜和数字图像分析，我们现在报道在大鼠胸主动脉发育过程中表达相对较高水平的连接蛋白43，其时间与报道的平滑肌细胞增殖和弹性膜层分泌的时间相关。表达的主要高峰发生在出生后7天，第二个不太明显的高峰发生在出生后72天。间隙连接水平的主要峰值似乎与出生后血压升高和主动脉中层增厚相吻合。随着平滑肌细胞向收缩表型调节并完成生长，间隙连接标记的数量下降到正常的成人水平。结果表明在主动脉生长和形成过程中，直接的细胞间通信与合成表型平滑肌细胞活性之间存在关联。 （C）1997 Academic Press Limited。 [参考：48]

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