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首页> 外文期刊>Cell biology international. >Overexpression of CD147 in ovarian cancer is initiated by the hypoxic microenvironment.
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Overexpression of CD147 in ovarian cancer is initiated by the hypoxic microenvironment.

机译：缺氧的微环境启动了CD147在卵巢癌中的过度表达。

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Ovarian cancer is a lethal malignant tumour characterised by activated invasion, distant metastasis, anti-cancer drug resistance, angiogenesis and metabolism. CD147, an extracellular matrix metalloproteinase inducer, is overexpressed in most ovarian tumours and plays an important role in the progression of ovarian cancer and other malignant tumours. However, the factor(s) initiating this overexpression is unknown. Because of rapid reproduction and their hypoxic microenvironment, malignant tumours use glycolysis for energy, and lactic acid produced is harmful to the cells. For survival, excessive lactate needs to be transported by monocarboxylate transporters (MCTs). Functioning of MCT1 and MCT4 require the ancillary of CD147. The gene for CD147 possesses two hypoxia-inducible factors binding sites in its 3'-flank. It is logical to postulate that the hypoxic microenvironment is a major initiator of the overexpression of CD147, thus conferring on ovarian cancers their malignant properties. A model that can represent spontaneous ovarian cancer is necessary to verify this hypothesis.
机译：卵巢癌是一种致命的恶性肿瘤，其特征在于活化的浸润，远处转移，抗癌药耐药性，血管生成和代谢。 CD147是一种细胞外基质金属蛋白酶诱导剂，在大多数卵巢肿瘤中均过表达，并在卵巢癌和其他恶性肿瘤的进展中起重要作用。但是，启动此过表达的因素未知。由于快速繁殖及其低氧的微环境，恶性肿瘤利用糖酵解获取能量，产生的乳酸对细胞有害。为了生存，过量的乳酸需要通过单羧酸盐转运蛋白（MCT）转运。 MCT1和MCT4的功能需要CD147的辅助。 CD147的基因在其3'侧翼具有两个缺氧诱导因子结合位点。逻辑上假设缺氧的微环境是CD147过表达的主要诱因，因此赋予卵巢癌其恶性特性。能够代表自发性卵巢癌的模型对于验证该假设是必要的。

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