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首页> 外文期刊>Cell and Tissue Research >Role of the extracellular matrix in lymphocyte migration.
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Role of the extracellular matrix in lymphocyte migration.

机译：细胞外基质在淋巴细胞迁移中的作用。

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摘要

The extracellular matrix (ECM) exists in various biochemical and structural forms that can act either as a barrier to migrating leukocytes, in the case of basement membranes, or provide a physical scaffold supporting or guiding migration (interstitial matrix). This review focuses on basement membranes and our current knowledge of the way that leukocytes transmigrate this protein barrier, with emphasis on T lymphocytes. Recent data suggest that the classical concept of cell-matrix adhesion requires revision with respect to leukocyte-ECM interactions. Whereas specific receptors may be required for leukocyte recognition of ECM molecules or three-dimensional structural domains, the role of adhesion in migration as perceived from the traditional studies of adherent cell-ECM interactions is less clear. Further, the indirect effects of ECM such as the binding and presentation of cytokines or chemotactic factors may more profoundly influence the directed migration of normally non-adherent leukocytes than the migration of adherent cells such as epithelial cells or fibroblasts. Proteases (in particular matrix metalloproteinases) released at sites of inflammation can selectively process ECM, cell surface molecules or soluble factors, which may result in the release of bioactive fragments that can function as chemoattractants for different leukocyte subsets or may modulate the activity/function of resident mesenchymal and immune cells. Current findings suggest that different leukocyte types employ different mechanisms to migrate across or through the ECM; this might be determined by the composition and organization of the ECM itself.
机译：细胞外基质（ECM）以各种生物化学和结构形式存在，在基底膜的情况下，它们可以充当白细胞迁移的屏障，或者提供支持或指导迁移的物理支架（间质基质）。这篇综述着重于基底膜和我们目前对白细胞迁移这种蛋白质屏障的方式的了解，重点是T淋巴细胞。最新数据表明，细胞-基质粘附的经典概念需要对白细胞-ECM相互作用进行修订。尽管白细胞识别ECM分子或三维结构域可能需要特定的受体，但是从粘附细胞-ECM相互作用的传统研究中发现粘附在迁移中的作用尚不清楚。此外，ECM的间接作用，例如细胞因子或趋化因子的结合和呈递，可能比正常粘附的白细胞的定向迁移比粘附细胞（如上皮细胞或成纤维细胞）的迁移更深刻地影响。在炎症部位释放的蛋白酶（尤其是基质金属蛋白酶）可以选择性地处理ECM，细胞表面分子或可溶性因子，从而导致释放出生物活性片段，这些片段可以作为不同白细胞亚群的趋化因子或调节其活性/功能。常驻间充质和免疫细胞。目前的发现表明，不同类型的白细胞采用不同的机制跨ECM或通过ECM迁移。这可能取决于ECM本身的组成和组织。

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