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首页> 外文期刊>Cell biology international. >EXPRESSION OF ALPHA-4 AND BETA-2 NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT MRNA AND LOCALIZATION OF ALPHA-BUNGAROTOXIN BINDING PROTEINS IN THE RAT VESTIBULAR PERIPHERY
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EXPRESSION OF ALPHA-4 AND BETA-2 NICOTINIC ACETYLCHOLINE RECEPTOR SUBUNIT MRNA AND LOCALIZATION OF ALPHA-BUNGAROTOXIN BINDING PROTEINS IN THE RAT VESTIBULAR PERIPHERY

机译：大鼠前庭外周血中α-4和β2烟碱乙酰胆碱受体亚单位mRNA的表达和α-邦戈毒素的结合蛋白的定位

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In situ hybridization histochemistry was used to map the distribution of alpha 2, alpha 3, alpha 4, and beta 2 nAChR subunit mRNAs throughout the peripheral vestibular system of the rat. The alpha 4 and beta 2 nAChR subunit genes were co-expressed by populations of primary afferent neurons within Scarpa's ganglion, while there was no expression of the alpha 2, alpha 3, alpha 4, or beta 2 nAChR subunit genes by type I or type II vestibular hair cells. alpha-bungarotoxin binding to nAChRs in the vestibular end-organs was primarily limited to the afferent chalices surrounding type I hair cells and the basal aspect of type II hair cells. These data suggest that nAChRs composed of alpha 4 and beta 2 subunits are localized on afferent chalices innervating the type I vestibular hair cells and that the direct cholinergic efferent innervation of the type II vestibular hair cells utilizes nAChR composed of other subunits.
机译：使用原位杂交组织化学方法绘制整个大鼠前庭系统中α2，α3，α4和β2nAChR亚基mRNA的分布图。 alpha 4和beta 2 nAChR亚基基因由Scarpa神经节内的初级传入神经元群体共表达，而没有按类型I或类型表达alpha 2，alpha 3，alpha 4或beta 2 nAChR亚基基因。二，前庭毛细胞。与前庭末端器官中的nAChRs结合的α-真菌毒素主要限于I型毛细胞周围的传入圣杯和II型毛细胞的基础方面。这些数据表明，由α4和β2亚基组成的nAChR位于神经支配I型前庭毛细胞的传入圣杯上，而II型前庭毛细胞的直接胆碱能传入神经支配利用了由其他亚基组成的nAChR。

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