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首页> 外文期刊>Cell biology international. >HLA-G in murine peripheral blood after interruption of pregnancy.
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HLA-G in murine peripheral blood after interruption of pregnancy.

机译：妊娠中断后鼠外周血中的HLA-G。

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摘要

HLA-G antigens are highly expressed in maternal peripheral blood during early pregnancy in transgenic mice. In this study, we determined the levels of HLA-G in white blood cells during early pregnancy and after interruption of pregnancy in triple transgenic mice (H-2K(b)/HLA-G, hbeta2m, and hCD2/hCD8-TRI). The pregnancies were interrupted on day 7 using the anti-progesterone agent mifepristone (RU486). Blood samples of 20 pregnant TRI mice were taken and the HLA-G levels were determined on days 2, 4 and 6 of pregnancy and on days 9, 11 and 13 after fertilization. The monoclonal antibody W6/32, specific for monomorphic determinant HLA class I molecules, was used in combination with an immunolocalization method using a photonic microscope. The HLA-G levels increased gradually on days 2, 4 and 6 of pregnancy, and the interruption of pregnancy on day 7 was followed by a decrease of HLA-G levels. The data indicate that pregnancy is characterized by the early presence of HLA-G in maternal peripheral blood inTRI transgenic mice and suggest that HLA-G may serve as a useful indicator for pregnancy maintenance and well-being.
机译：在转基因小鼠的妊娠早期，HLA-G抗原在母亲外周血中高表达。在这项研究中，我们确定了三只转基因小鼠（H-2K（b）/ HLA-G，hbeta2m和hCD2 / hCD8-TRI）在早期妊娠期间和妊娠中断后白细胞中HLA-G的水平。在第7天使用抗孕激素药米非司酮（RU486）中断了妊娠。采集20只怀孕的TRI小鼠的血样，并在怀孕第2、4和6天以及受精后第9、11和13天测定HLA-G水平。对单态决定簇HLA I类分子具有特异性的单克隆抗体W6 / 32与使用光子显微镜的免疫定位方法结合使用。 HLA-G水平在怀孕的第2、4和6天逐渐增加，在第7天中断妊娠后，HLA-G水平下降。数据表明，怀孕的特征是母体外周血INTRI转基因小鼠中早期存在HLA-G，这表明HLA-G可以作为维持妊娠和幸福感的有用指标。

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